Blar i Department of Biomedicine på tittel
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In-depth cerebrospinal fluid quantitative proteome and deglycoproteome analysis: presenting a comprehensive picture of pathways and processes affected by multiple sclerosis
(Peer reviewed; Journal article, 2017)In the current study, we conducted a quantitative in-depth proteome and deglycoproteome analysis of cerebrospinal fluid (CSF) from relapsing-remitting multiple sclerosis (RRMS) and neurological controls using mass spectrometry ... -
In-depth characterization of the cerebrospinal fluid (CSF) proteome displayed through the CSF proteome resource (CSF-PR)
(Peer reviewed; Journal article, 2014-11)In this study, the human cerebrospinal fluid (CSF) proteome was mapped using three different strategies prior to Orbitrap LC-MS/MS analysis: SDS-PAGE and mixed mode reversed phase-anion exchange for mapping the global CSF ... -
In-vitro characterization of STUB1 mutations in recessively inherited spinocerebellar ataxia-16
(Master thesis, 2016-05-31)Autosomal Recessive Cerebellar Ataxia (ARCA) develops as a result of inefficient protein turnover and further accumulation of damaged proteins inside the cells. Some of mutations associated with ARCA are identified in the ... -
Increased Fibrosis and Interstitial Fluid Pressure in Two Different Types of Syngeneic Murine Carcinoma Grown in Integrin β3-Subunit Deficient Mice
(Peer reviewed; Journal article, 2012-03-30)Stroma properties affect carcinoma physiology and direct malignant cell development. Here we present data showing that αVβ3 expressed by stromal cells is involved in the control of interstitial fluid pressure (IFP), ... -
Increased infiltration and tolerised antigen-specific CD8+ TEM cells in tumor but not peripheral blood have no impact on survival of HCMV+ glioblastoma patients
(Peer reviewed; Journal article, 2017)Human cytomegalovirus (HCMV) antigens in glioblastoma (GBM) present opportunities for personalised immunotherapy. However, their presence in GBM tissue is still under debate, and evidence of their impact on functional ... -
Increased microvascular permeability in mice lacking Epac1 (Rapgef3)
(Peer reviewed; Journal article, 2017-02)Aim: Maintenance of the blood and extracellular volume requires tight control of endothelial macromolecule permeability, which is regulated by cAMP signalling. This study probes the role of the cAMP mediators rap guanine ... -
Increased plasma colloid osmotic pressure facilitates the uptake of therapeutic macromolecules in a xenograft tumour model
(Peer reviewed; Journal article, 2009-08)Elevated tumor interstitial fluid pressure (TIFP) is a characteristic of most solid tumors. Clinically, TIFP may hamper the uptake of chemotherapeutic drugs into the tumor tissue reducing their therapeutic efficacy. In ... -
Induction of mitochondrial biogenesis and respiration is associated with mTOR regulation in hepatocytes of rats treated with the pan-PPAR activator tetradecylthioacetic acid (TTA)
(Peer reviewed; Journal article, 2013-01)The hypolipidemic effect of peroxisome proliferator-activated receptor (PPAR) activators has been explained by increasing mitochondrial fatty acid oxidation, as observed in livers of rats treated with the pan-PPAR activator ... -
Inference of low and high-grade glioma gene regulatory networks delineates the role of Rnd3 in establishing multiple hallmarks of cancer
(Peer reviewed; Journal article, 2015-07-01)Gliomas are a highly heterogeneous group of brain tumours that are refractory to treatment, highly invasive and pro-angiogenic. Glioblastoma patients have an average survival time of less than 15 months. Understanding the ... -
Inflammatory targeted assessment and laser treatment of knee osteoarthritis : Rater reliability of pain pressure threshold algometry and effectiveness of Low-Level Laser Therapy
(Doctoral thesis, 2022-11-03)Bakgrunn: Ved kneartrose er et høyere nivå av inflammasjon assosiert med mer intens smerte og raskere sykdomsprogresjon. Å redusere kneinflammasjon anbefales derfor som behandlingsmål. Inflammatorisk mediert hyperalgesi ... -
Influence of organ motion on conformal vs. intensity-modulated pelvic radiotherapy for prostate cancer
(Peer reviewed; Journal article, 2008-08-01) -
Inhibition of extracellular vesicle-derived miR-146a-5p decreases progression of melanoma brain metastasis via Notch pathway dysregulation in astrocytes
(Journal article; Peer reviewed, 2023)Melanoma has the highest propensity of all cancers to metastasize to the brain with a large percentage of late-stage patients developing metastases in the central nervous system (CNS). It is well known that metastasis ... -
Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis
(Peer reviewed; Journal article, 2019-04-10)Melanoma patients carry a high risk of developing brain metastases, and improvements in survival are still measured in weeks or months. Durable disease control within the brain is impeded by poor drug penetration across ... -
Inhibition of the Human Hsc70 System by Small Ligands as a Potential Anticancer Approach
(Journal article; Peer reviewed, 2021)Heat shock protein (Hsp) synthesis is upregulated in a wide range of cancers to provide the appropriate environment for tumor progression. The Hsp110 and Hsp70 families have been associated to cancer cell survival and ... -
Inhibition of Tryptophan Hydroxylases and Monoamine Oxidase-A by the Proton Pump Inhibitor, Omeprazole—In Vitro and In Vivo Investigations
(Journal article; Peer reviewed, 2020)Serotonin (5-HT) is a hormone and neurotransmitter that modulates neural activity as well as a wide range of other physiological processes including cardiovascular function, bowel motility, and platelet aggregation. 5-HT ... -
Inhibition of VMAT2 by β2-adrenergic agonists, antagonists, and the atypical antipsychotic ziprasidone
(Journal article; Peer reviewed, 2022)Vesicular monoamine transporter 2 (VMAT2) is responsible for packing monoamine neurotransmitters into synaptic vesicles for storage and subsequent neurotransmission. VMAT2 inhibitors are approved for symptomatic treatment ... -
Inhibitory inputs to an inhibitory interneuron: Spontaneous postsynaptic currents and GABA_A receptors of A17 amacrine cells in the rat retina
(Journal article; Peer reviewed, 2022)Amacrine cells constitute a large and heterogeneous group of inhibitory interneurons in the retina. The A17 amacrine plays an important role for visual signalling in the rod pathway microcircuit of the mammalian retina. ... -
Innate Lymphoid Cells in Skin Homeostasis and Malignancy
(Journal article; Peer reviewed, 2021)Innate lymphoid cells (ILCs) are mostly tissue resident lymphocytes that are preferentially enriched in barrier tissues such as the skin. Although they lack the expression of somatically rearranged antigen receptors present ... -
Insights into the cellular role of Serine19 phosphorylation in tyrosine hydroxylase
(Master thesis, 2016-06-01)Tyrosine hydroxylase (TH) is the rate limiting enzyme that catalyzes the first step in the biosynthesis of catecholamines. The posttranslational modification of its regulatory domain controls the regulation of TH enzyme ... -
Instability in NAD+ metabolism leads to impaired cardiac mitochondrial function and communication
(Journal article; Peer reviewed, 2021)Poly(ADP-ribose) polymerase (PARP) enzymes initiate (mt)DNA repair mechanisms and use nicotinamide adenine dinucleotide (NAD+) as energy source. Prolonged PARP activity can drain cellular NAD+ reserves, leading to de-regulation ...