Blar i Department of Biomedicine på tittel
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Multi-national Gene Expression Profiling of Oral Squamous Cell Carcinomas. Biological Pathways Regardless of Differences Related to Life-style and Ethnicity
(Doctoral thesis, 2012-02-02)Oral squamous cell carcinoma (OSCC) is a major health problem in many developing countries, representing more than 25% of all new cancer cases in some countries such as India and Sri Lanka. Cigarette smoking, smokeless ... -
Multimodal imaging of gliomas in the context of evolving cellular and molecular therapies
(Peer reviewed; Journal article, 2014-09-30)The vastmajority ofmalignant gliomas relapse after surgery and standard radio-chemotherapy. Novelmolecular and cellular therapies are thus being developed, targeting specific aspects of tumor growth.While histopathology ... -
Multimodal Imaging of Physiologic Changes Induced by Anti-Angiogenic Therapy in Glioblastoma
(Doctoral thesis, 2014-12-18)Glioblastoma (GBM) is the most frequent and malignant form of primary brain tumors. The standard of care for this disease consists in surgical resection, followed by radiotherapy and chemotherapy. Yet, the infiltrative ... -
Multiparametric brain MRI and deep learning models applied to segmentation and prediction in patients with glioma
(Doctoral thesis, 2024-08-28)Avhandlingen undersøker metoder og algoritmer for hjernetumor (gliom) segmenter- ing, med prediksjon av histologisk gradering, og anatomisk profilering fra MR-bilder. En viktig motivasjon for dette arbeidet har vært ... -
Multiphoton excitation microscopy for the reconstructionand analysis of single neuron morphology
(Neuromethods, Chapter; Peer reviewed, 2019)Neurons are the main cellular components of the circuits of the central nervous system (CNS). The dendritic and axonal morphology of individual neurons display marked variability between neurons in different regions of the ... -
Multiple sclerosis and myelin basic protein: insights into protein disorder and disease
(Journal article; Peer reviewed, 2022)Myelin basic protein (MBP) is an abundant protein in central nervous system (CNS) myelin. MBP has long been studied as a factor in the pathogenesis of the autoimmune neurodegenerative disease multiple sclerosis (MS). MS ... -
Mutant IDH1 Differently Affects Redox State and Metabolism in Glial Cells of Normal and Tumor Origin
(Peer reviewed; Journal article, 2019-12-16)IDH1R132H (isocitrate dehydrogenase 1) mutations play a key role in the development of low-grade gliomas. IDH1wt converts isocitrate to α-ketoglutarate while reducing nicotinamide adenine dinucleotide phosphate (NADP+), ... -
Myelin proteins from the peripheral nervous system : Structures and interactions with lipid membrane
(Doctoral thesis, 2024-08-29)Saltare (å hoppe) beskriver den grunnleggende funksjonen myelin har i nervesystemet. Myelin er en flerlaget fettmembran som omslutter nervecellenes aksoner og effektiviserer signalformidlingen betraktelig ved å øke hastigheten ... -
Myelin-derived and putative molecular mimic peptides share structural properties in aqueous and membrane-like environments
(Peer reviewed; Journal article, 2017-03-24)Background: Despite intense research, the causes of various neurological diseases remain enigmatic to date. A role for viral or bacterial infection and associated molecular mimicry has frequently been suggested in the ... -
The mzIdentML data standard version 1.2, supporting advances in proteome informatics
(Peer reviewed; Journal article, 2017-07-01)The first stable version of the Proteomics Standards Initiative mzIdentML open data standard (version 1.1) was published in 2012—capturing the outputs of peptide and protein identification software. In the intervening ... -
N-terminal acetylation of actin by NAA80 is essential for structural integrity of the Golgi apparatus
(Journal article; Peer reviewed, 2020)N-alpha-acetyltransferase 80 (NAA80) was recently demonstrated to acetylate the N-terminus of actin, with NAA80 knockout cells showing actin cytoskeleton-related phenotypes, such as increased formation of membrane protrusions ... -
The N-terminal sequence of tyrosine hydroxylase is a conformationally versatile motif that binds 14-3-3 proteins and membranes
(Peer reviewed; Journal article, 2014-01-09)Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of catecholamine neurotransmitters, and a reduction in TH activity is associated with several neurological diseases. Human TH is regulated, among ... -
Na+ is shifted from the extracellular to the intracellular compartment and is not inactivated by glycosaminoglycans during high salt conditions in rats
(Journal article; Peer reviewed, 2022)Recently, studies have emerged suggesting that the skin plays a role as major Na+ reservoir via regulation of the content of glycosaminoglycans and osmotic gradients. We investigated whether there were electrolyte gradients ... -
NAA10 p.(D10G) and NAA10 p.(L11R) variants hamper formation of the NatA N-terminal acetyltransferase complex
(Journal article; Peer reviewed, 2020)The majority of the human proteome is subjected to N-terminal (Nt) acetylation catalysed by N-terminal acetyltransferases (NATs). The NatA complex is composed of two core subunits—the catalytic subunit NAA10 and the ribosomal ... -
NAA10 p.(N101K) disrupts N-terminal acetyltransferase complex NatA and is associated with developmental delay and hemihypertrophy
(Journal article; Peer reviewed, 2020)Nearly half of all human proteins are acetylated at their N-termini by the NatA N-terminal acetyltransferase complex. NAA10 is evolutionarily conserved as the catalytic subunit of NatA in complex with NAA15, but may also ... -
The native structure of annexin A2 peptides in hydrophilic environment determines their anti-angiogenic effects
(Peer reviewed; Journal article, 2015-03-13)The progression of aggressive cancer occurs via angiogenesis and metastasis makes these processes important targets for the development of anti-cancer agents. However, recent studies have raised the concern that selective ... -
The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma
(Peer reviewed; Journal article, 2019-09-27)Galangin (GG), a flavonoid, elicits a potent antitumor activity in diverse cancers. Here, we evaluated the efficacy of GG in the treatment of human glioblastoma multiforme (GBM) and investigated the molecular basis for its ... -
Natural killer cells in intracranial neoplasms: presence and therapeutic efficacy against brain tumours
(Peer reviewed; Journal article, 2014-01)Natural killer (NK) cells are lymphocytes that play an important role in anti-tumour immunity. Their potential against brain cancer has been demonstrated in vitro and in vivo, both as a direct anti-tumour agent and in ... -
Neoadjuvant chemotherapy in breast cancer-response evaluation and prediction of response to treatment using dynamic contrast-enhanced and diffusion-weighted MR imaging
(Peer reviewed; Journal article, 2011)Objective To explore the predictive value of MRI parameters and tumour characteristics before neoadjuvant chemotherapy (NAC) and to compare changes in tumour size and tumour apparent diffusion coefficient (ADC) during ... -
Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality.
(Peer reviewed; Journal article, 2019-04-11)Summary Emerging evidence suggests that Parkinson's disease (PD), besides being an age-associated disorder, might also have a neurodevelopment component. Disruption of mitochondrial homeostasis has been highlighted as a ...