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Relevance of Electrostatics for the Interaction of Tyrosine Hydroxylase with Porous Silicon Nanoparticles
(Journal article; Peer reviewed, 2021)Tyrosine hydroxylase (TH) is the enzyme catalyzing the rate-limiting step in the synthesis of dopamine in the brain. Developing enzyme replacement therapies using TH could therefore be beneficial to patient groups with ... -
Reliable FASP-based procedures for optimal quantitative proteomic and phosphoproteomic analysis on samples from acute myeloid leukemia patients
(Peer reviewed; Journal article, 2016-06-21)Background Satisfactory sample preparation for mass spectrometry-based analysis is a critical step in the proteomics workflow. The quality and reproducibility of sample preparation can determine the coverage and confidence ... -
Remote postconditioning by humoral factors in effluent from ischemic preconditioned rat hearts is mediated via PI3K/Akt-dependent cell-survival signaling at reperfusion
(Peer reviewed; Journal article, 2010-12-29)Short non-lethal ischemic episodes administered to hearts prior to (ischemic preconditioning, IPC) or directly after (ischemic postconditioning, IPost) ischemic events facilitate myocardial protection. Transferring coronary ... -
Replication protein A prevents accumulation of single-stranded telomeric DNA in cells that use alternative lengthening of telomeres
(Peer reviewed; Journal article, 2007-10-24)The activation of a telomere maintenance mechanism is required for cancer development in humans. While most tumors achieve this by expressing the enzyme telomerase, a fraction (5–15%) employs a recombination-based mechanism ... -
A reproducible brain tumour model established from human glioblastoma biopsies
(Peer reviewed; Journal article, 2009-12-29)Background: Establishing clinically relevant animal models of glioblastoma multiforme (GBM) remains a challenge, and many commonly used cell line-based models do not recapitulate the invasive growth patterns of patient ... -
Resibufogenin Targets the ATP1A1 Signaling Cascade to Induce G2/M Phase Arrest and Inhibit Invasion in Glioma
(Journal article; Peer reviewed, 2022)Resibufogenin (RB) is a major active ingredient in the traditional Chinese medicine Chansu and has garnered considerable attention for its efficacy in the treatment of cancer. However, the anticancer effects and underlying ... -
Revealing and Harnessing Tumour-Associated Microglia/Macrophage Heterogeneity in Glioblastoma
(Journal article; Peer reviewed, 2020)Cancer heterogeneity and progression are subject to complex interactions between neoplastic cells and their microenvironment, including the immune system. Although glioblastomas (GBMs) are classified as ‘cold tumours’ with ... -
Riboswitches as Drug Targets for Antibiotics
(Journal article; Peer reviewed, 2021)Riboswitches reside in the untranslated region of RNA and regulate genes involved in the biosynthesis of essential metabolites through binding of small molecules. Since their discovery at the beginning of this century, ... -
Right ventricular postsystolic shortening: Resolution after opening a totally occluded right coronary artery
(Journal article; Peer reviewed, 2022)Acute myocardial ischemia induces reduced systolic shortening and causes postsystolic shortening (PSS). Right ventricular (RV) PSS in coronary artery disease has been less studied. We present here the case of a 51-year-old ... -
Risk factors of suicidal spectrum behaviors in adults and adolescents with attention-deficit / hyperactivity disorder – a systematic review
(Journal article; Peer reviewed, 2023-08-21)Introduction: Adolescents and adults with attention-deficit/hyperactivity disorder (ADHD) are at increased risk of suicidal spectrum behaviors (SSBs). However, there is limited knowledge about risk factors triggering SSBs ... -
RNA sequencing and proteomic profiling reveal different alterations by dietary methylmercury in the hippocampal transcriptome and proteome in BALB/c mice
(Journal article; Peer reviewed, 2021)Methylmercury (MeHg) is a highly neurotoxic form of mercury (Hg) present in seafood. Here, we recorded and compared proteomic and transcriptomic changes in hippocampus of male BALB/c mice exposed to two doses of MeHg. Mice ... -
RNA splicing factor USP39 promotes glioma progression by inducing TAZ mRNA maturation
(Peer reviewed; Journal article, 2019)Increasing evidence demonstrates that ubiquitin specific protease 39 (USP39) plays an oncogenic role in various human tumors. Here, using expression analysis of the publicly available Oncomine database, clinical glioma ... -
RNA-binding is an ancient trait of the Annexin family
(Journal article; Peer reviewed, 2023)Introduction: The regulation of intracellular functions in mammalian cells involves close coordination of cellular processes. During recent years it has become evident that the sorting, trafficking and distribution of ... -
The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons
(Peer reviewed; Journal article, 2017-11)Brain-derived neurotrophic factor (BDNF) is an important mediator of long-term synaptic potentiation (LTP) in the hippocampus. The local effects of BDNF depend on the activation of translation activity, which requires the ... -
The Role of Age in Cellular Responses to Microenvironmental Cues as a Breast Cancer Susceptibility Factor
(Doctoral thesis, 2016-05-09)Aging is the critical risk factor for many forms of cancer. We used the mammary gland as a model system to study the impact of age on human epithelia in which age is the greatest risk factor for cancer. Dysfunctional ... -
The role of autoantibodies in cell mediated autoimmune Addison`s disease
(Master thesis, 2012-05-31)Background: Addison`s disease (primary adrenal insufficiency) is a prototypic organ-specific autoimmune disease affecting the adrenal cortex. Autoimmune Addison`s disease (AAD) is often characterized by autoantibodies ... -
The Role of Axl in Cancer and Stem Cell Plasticity: in vivo Lineage Tracing and Imaging Mass Cytometry Analysis
(Master thesis, 2019-11-14) -
The role of Axl in melanoma metastasis
(Master thesis, 2015-05-31)Melanoma is a highly invasive and metastatic cancer, thus understanding the mechanism of melanoma metastasis is a major issue. In our study, the objective is to elucidate the role of the receptor tyrosine kinase Axl in ... -
Role of Caveolin-1 in Hypoxia and Proneural to Mesenchymal Transition of Glioblastoma
(Master thesis, 2018-06-29)Glioblastomas (GBM), a grade IV astrocytoma, is the most common and aggressive primary brain tumors in adults, associated with short survival and uniformly fatal outcome irrespective of treatment. GBM is highly heterogeneous ... -
Role of gingival lymphatics in tissue fluid balance and periodontal disease development
(Doctoral thesis, 2012-05-25)Background: The gingiva is frequently challenged to oral bacteria which are able to induce inflammatory responses with increased fluid filtration and edema formation in the tissue. Under given circumstances periodontal ...