Browsing Department of Clinical Medicine by Title
Now showing items 1363-1382 of 2116
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mtDNA nt13708A Variant Increases the Risk of Multiple Sclerosis
(Peer reviewed; Journal article, 2008-02-13)Background: Mitochondrial DNA (mtDNA) polymorphism is a possible factor contributing to the maternal parent-of-origin effect in multiple sclerosis (MS) susceptibility. Methods and Findings: In order to investigate the role ... -
The mucinous domain of pancreatic carboxyl-ester lipase (CEL) contains core 1/core 2 O-glycans that can be modified by ABO blood group determinants
(Peer reviewed; Journal article, 2018)Carboxyl-ester lipase (CEL) is a pancreatic fat-digesting enzyme associated with human disease. Rare mutations in the CEL gene cause a syndrome of pancreatic exocrine and endocrine dysfunction denoted MODY8, whereas a ... -
A multicenter study on Leigh syndrome: disease course and predictors of survival
(Peer reviewed; Journal article, 2014-04-15)Background: Leigh syndrome is a progressive neurodegenerative disorder, associated with primary or secondary dysfunction of the mitochondrial oxidative phosphorylation. Despite the fact that Leigh syndrome is the most ... -
Multidisciplinary intervention versus brief intervention in specialist healthcare. Attempting to improve outcomes for patients on sick leave with musculoskeletal pain
(Doctoral thesis, 2018-12-11)Background: Musculoskeletal pain (MSK), such as low back pain (LBP), neck pain and widespread pain, is among the most common health problems in industrial countries. Subsequently, MSK is associated with substantial healthcare ... -
Multifaceted intervention including Facebook-groups to improve guideline-adherence in ICU: A quasi-experimental interrupted time series study
(Journal article; Peer reviewed, 2021)Background: The impact of social media, with its speed, reach and accessibility, in interventions aimed to improve adherence to guidelines such as assessment of Pain, Agitation/Sedation and Delirium (PAD) in intensive care ... -
A multilevel, step-based model to evaluate progress in procedure efficiency for laparoscopic appendicectomy in surgical training: structured evaluation using 'ebb-and-flow' and 'string-of-pearls' concepts
(Journal article; Peer reviewed, 2022)Background Surgical training is aimed towards entrusted professional activity to obtain operative independence. Laparoscopic appendicectomy is performed early in training but except for simulators, real-life evaluation ... -
Multimodal multi-center analysis of electroconvulsive therapy effects in depression: Brainwide gray matter increase without functional changes
(Journal article; Peer reviewed, 2022)Background: Electroconvulsive therapy (ECT) is an effective treatment for severe depression and induces gray matter (GM) increases in the brain. Small-scale studies suggest that ECT also leads to changes in brain functioning, ... -
A multiomics disease progression signature of low-risk ccRCC
(Journal article; Peer reviewed, 2022)Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer. Identification of ccRCC likely to progress, despite an apparent low risk at the time of surgery, represents a key clinical issue. From a cohort of ... -
Multiple adversity: Childhood abuse, adult abuse, and perinatal depression in women with multiple sclerosis : A register-based cohort study
(Doctoral thesis, 2024-02-23)Bakgrunn: Stress kan spille en rolle ved multippel sklerose (MS). Stress i barndommen forårsaket av vold og overgrep er assosiert med økt risiko for kroniske sykdommer i voksen alder. Det er ukjent om slikt stress kan ... -
Multiple organ failure after trauma affects even long- term survival and functional status
(Peer reviewed; Journal article, 2007-09-04)Background The aim of this study was to assess the incidence of organ failure in trauma patients treated in an intensive care unit (ICU), and to study the relationship between organ failure and long-term survival and ... -
Multiple primary malignancies in patients with Renal Cell Carcinoma. - A national population-based cohort study
(Journal article; Peer reviewed, 2006)Objective: To determine the possibly greater occurrence of multiple malignancies in patients with renal cell carcinoma (RCC). Patients and methods: In the 7-year period 1987–93, all 1425 patients aged 15–70 years with ... -
Multiple sclerosis -the impact of environmental- and lifestyle factors
(Doctoral thesis, 2021-04-15)Background: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), likely caused by an interaction of genetic and environmental factors. Epstein-Barr virus infection, low serum ... -
Multiple sclerosis and pregnancy: pregnancy, delivery and birth outcome in woman with multiple sclerosis
(Doctoral thesis, 2008-09-03)This study provides information regarding birth-giving in women with multiple sclerosis (MS). MS is a common disease in the western world and causes disability in young adults and, like most immune mediated diseases, affects ... -
Multiple simultaneous embolic cerebral infarctions 11 months after COVID-19
(Journal article; Peer reviewed, 2021-08-18)Background: The coronavirus disease (COVID-19) pandemic has led to an unprecedented worldwide burden of disease. However, little is known of the longer-term implications and consequences of COVID-19. One of these may be a ... -
Musculoskeletal pain patterns and association between dizziness symptoms and pain in patients with long term dizziness – a cross-sectional study
(Journal article; Peer reviewed, 2023)Background The impact of long-term dizziness is considerable both on the personal level and in society and may lead to self-imposed restrictions in daily activities and social relations due to fear of triggering the ... -
Mutation analysis by deep sequencing of pancreatic juice from patients with pancreatic ductal adenocarcinoma
(Peer reviewed; Journal article, 2019-01-05)Background Reliable methods are needed to identify patients with early-stage cancer or high-grade precancerous lesions in the pancreas. Analysis of pancreatic juice to detect somatic mutations could represent one such ... -
Mutations and gene amplifications in Endometrial Carcinomas. “Clinical characteristics and potential targets for therapy related to KRAS, MYC, ATAD2, PIK3CA and FGFR2 alterations”
(Doctoral thesis, 2013-09-20)Background: Incidence of endometrial cancer is increasing in industrialised countries. Despite early diagnosis and generally good prognosis, around one fourth of cases follow an aggressive path with few effective treatment ... -
Myasthenia gravis can have consequences for pregnancy and the developing child
(Journal article; Peer reviewed, 2020)Myasthenia gravis (MG) with onset below 50 years, thymic hyperplasia and acetylcholine receptor (AChR) antibodies is more common in females than in males. For a relatively large group of MG patients, pregnancy represents ... -
Myasthenia gravis, respiratory function, and respiratory tract disease
(Journal article; Peer reviewed, 2023)Myasthenia gravis (MG) is characterized by muscle weakness caused by autoantibodies that bind to the postsynaptic membrane at the neuromuscular junction and impair acetylcholine receptor function. Weakness of respiratory ...