Browsing Department of Biomedicine by Title
Now showing items 717-736 of 742
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U-251 revisited: genetic drift and phenotypic consequences of long-term cultures of glioblastoma cells
(Peer reviewed; Journal article, 2014-08)It is well known that in vitro subculture represents a selection pressure on cell lines, and over time this may result in a genetic drift in the cancer cells. In addition, long-term cultures harbor the risk of cross-contamination ... -
UCP1 induction during recruitment of Brown Adipocytes in White Adipose tissue is dependent on Cyclooxygenase activity
(Peer reviewed; Journal article, 2010-06-30)Background The uncoupling protein 1 (UCP1) is a hallmark of brown adipocytes and pivotal for cold- and diet-induced thermogenesis. Methodology/Principal Findings Here we report that cyclooxygenase (COX) activity and ... -
Ultrasound-mediated delivery and distribution of polymeric nanoparticles in the normal brain parenchyma of a metastatic brain tumour model
(Peer reviewed; Journal article, 2018-01-16)The treatment of brain diseases is hindered by the blood-brain barrier (BBB) preventing most drugs from entering the brain. Focused ultrasound (FUS) with microbubbles can open the BBB safely and reversibly. Systemic drug ... -
Understanding proteostasis dysregulation in phenylketonuria – a paradigm disease for inborn error of metabolism
(Doctoral thesis, 2022-09-06)Fenylketonuria (PKU) er en medfødt stoffskiftesykdom forårsaket av mutasjoner i genet for fenylalanin hydroksylase (PAH), og fører til ustabile og ofte feilfoldete enzymer med nedsatt evne til å metabolisere aminosyren ... -
Understanding the interaction between the co-chaperone DNAJC12 and tyrosine hydroxylase
(Master thesis, 2020-06-23) -
Upregulated integrin α11 in the stroma of cutaneous squamous cell carcinoma promotes skin carcinogenesis
(Journal article; Peer reviewed, 2022)Integrin α11β1 is a collagen-binding integrin that is needed to induce and maintain the myofibroblast phenotype in fibrotic tissues and during wound healing. The expression of the α11 is upregulated in cancer-associated ... -
Upregulated PDK4 expression is a sensitive marker of increased fatty acid oxidation
(Peer reviewed; Journal article, 2019)Fatty acid oxidation is a central fueling pathway for mitochondrial ATP production. Regulation occurs through multiple nutrient- and energy-sensitive molecular mechanisms. We explored if upregulated mRNA expression of the ... -
Ursodeoxycholic Acid Inhibits Glioblastoma Progression via Endoplasmic Reticulum Stress Related Apoptosis and Synergizes with the Proteasome Inhibitor Bortezomib
(Journal article; Peer reviewed, 2020)Ursodeoxycholic acid (UDCA) has demonstrated cancer suppressive potential in several tumors. Here, we investigated the antitumor potential and biochemical mechanism of UDCA on glioblastoma multiforme (GBM), the deadliest ... -
Use of big data and machine learning algorithms to extract possible treatment targets in neurodevelopmental disorders
(Journal article; Peer reviewed, 2023)Neurodevelopmental disorders (NDDs) impact multiple aspects of an individual's functioning, including social interactions, communication, and behaviors. The underlying biological mechanisms of NDDs are not yet fully ... -
Use of stable isotope dimethyl labeling coupled to selected reaction monitoring to enhance throughput by multiplexing relative quantitation of targeted proteins
(Peer reviewed; Journal article, 2012)In this manuscript, we present a proof-of-concept study for targeted relative protein quantitation workflow using chemical labeling in the form of dimethylation, coupled with selected reaction monitoring (dimethyl-SRM). ... -
Using mass spectrometry-based proteomics to improve the understanding of multiple sclerosis treatments
(Doctoral thesis, 2021-06-23)In this work, the effects of multiple sclerosis (MScl) treatments were investigated by quantitative proteomics. First, the effects of the anti-inflammatory drug Fingolimod was studied to see if the drug affected central ... -
Validity and accuracy of the Adult Attention-Deficit/Hyperactivity Disorder (ADHD) Self-Report Scale (ASRS) and the Wender Utah Rating Scale (WURS) symptom checklists in discriminating between adults with and without ADHD
(Journal article; Peer reviewed, 2020)Objective To validate the Adult ADHD Self‐Report Scale (ASRS) and the Wender Utah Rating Scale (WURS) in a well‐characterized sample of adult attention‐deficit/hyperactivity disorder (ADHD) patients and population ... -
Valtrate, an iridoid compound in Valeriana, elicits anti-glioblastoma activity through inhibition of the PDGFRA/MEK/ERK signaling pathway
(Journal article; Peer reviewed, 2023)Background Valtrate, a natural compound isolated from the root of Valeriana, exhibits antitumor activity in many cancers through different mechanisms. However, its efficacy for the treatment of glioblastoma (GBM), a ... -
Vascular endothelial growth factors and receptors - from normal dental pulp to apical pathology
(Doctoral thesis, 2016-02-12)The VEGFs -A, -B, -C, -D are important signaling molecules with pivotal implication in the growth of blood and lymphatic vessels, the so-called angio- and lymphangiogenesis. They exert their activities by binding to their ... -
VEGF-B hypertrophy predisposes to transition from diastolic to systolic heart failure in hypertensive rats
(Journal article; Peer reviewed, 2023)Aims: Cardiac energy metabolism is centrally involved in heart failure (HF), although the direction of the metabolic alterations is complex and likely dependent on the particular stage of HF progression. Vascular endothelial ... -
Viewing the proteome: How to visualize proteomics data?
(Peer reviewed; Journal article, 2015-04)Proteomics has become one of the main approaches for analyzing and understanding biological systems. Yet similar to other high-throughput analysis methods, the presentation of the large amounts of obtained data in easily ... -
Virtual Source Modelling of Photon Beams for Monte Carlo Based Radiation Therapy Treatment Planning
(Doctoral thesis, 2011-10-13)Modern radiotherapy (RT) techniques such as stereotactic body radiotherapy (SBRT), intensitymodulated radiotherapy (IMRT) or volumetric modulated arc therapy (VMAT) carries the potential of improving the quality of treatment. ... -
Visualization of metastatic melanoma cells by fluorescence microscopy and MRI using a novel glycogen nanoprobe
(Master thesis, 2014-06-05)The incidence of malignant melanoma has increased steadily during the last decades. Large portions of individuals with this particular skin cancer develop multiple brain metastases, which is associated with a particular ... -
Visualizing Arc protein dynamics and localization in the mammalian brain using AAV-mediated in situ gene labeling
(Journal article; Peer reviewed, 2023)The activity-regulated cytoskeleton-associated (Arc) protein is essential for synaptic plasticity and memory formation. The Arc gene, which contains remnants of a structural GAG retrotransposon sequence, produces a protein ... -
Voxel dimension optimization for probabilistic tractography in rat brain using 7T scanner
(Master thesis, 2015-06-01)Brain connectivity is an increasingly important research field within neuroscience. Using MRI technology it is now possible to measure diffusion to approximate the location of anatomical tracts in the brain or correlate ...