Blar i Department of Biomedicine på tittel
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Phosphoglycerate Mutase 1 Activates DNA Damage Repair via Regulation of WIP1 Activity
(Journal article; Peer reviewed, 2020)The metabolic enzyme phosphoglycerate mutase 1 (PGAM1) is overexpressed in several types of cancer, suggesting an additional function beyond its established role in the glycolytic pathway. We here report that PGAM1 is ... -
Phospholipase D in human blood platelets
(Doctoral thesis, 2008-05-30)We have studied phospholipase D (PLD) in human blood platelets. This enzyme hydrolyzes phosphatidylcholine to phosphatidic acid (PA) and choline, where PA is considered to be the main effector of PLDs function in cells. ... -
Phosphorylation at serine 31 targets tyrosine hydroxylase tovesicles for transport along microtubules
(Peer reviewed; Journal article, 2017)Tyrosine hydroxylase (TH) catalyzes the conversion of L-tyrosine into L-DOPA, which is the rate-limiting step in the synthesis of catecholamines, such as dopamine, in dopaminergergic neurons. Low dopamine levels and death ... -
PKM2 Interacts With the Cdk1-CyclinB Complex to Facilitate Cell Cycle Progression in Gliomas
(Journal article; Peer reviewed, 2022)PKM2 is a phosphotyrosine-binding glycolytic enzyme upregulated in many cancers, including glioma, and contributes to tumor growth by regulating cell cycle progression. We noted, however, that in multiple glioma cell lines, ... -
PKU mutation p.G46S prevents the stereospecific binding of l-phenylalanine to the dimer of human phenylalanine hydroxylase regulatory domain
(Peer reviewed; Journal article, 2017-02)Mammalian phenylalanine hydroxylase (PAH) has a potential allosteric regulatory binding site for l‐phenylalanine (l‐Phe), in addition to its catalytic site. This arrangement is supported by a crystal structure of a homodimeric ... -
PMEPA1 isoform a drives progression of glioblastoma by promoting protein degradation of the Hippo pathway kinase LATS1
(Peer reviewed; Journal article, 2019)The Hippo signaling pathway controls organ development and is also known, in cancer, to have a tumor suppressing role. Within the Hippo pathway, we here demonstrate, in human gliomas, a functional interaction of a transmembrane ... -
Post-translational modifications of Annexin A2 are linked to its association with perinuclear nonpolysomal mRNP complexes
(Peer reviewed; Journal article, 2017-02)Various post-translational modifications (PTMs) regulate the localisation and function of the multifunctional protein Annexin A2 (AnxA2). In addition to its various tasks as a cytoskeletal- and membrane-associated protein, ... -
Post-translational modifications of integrin ligands as pathogenic mechanisms in disease
(Peer reviewed; Journal article, 2014-11)Protein post-translational modifications like glycation, carbamylation and citrullination increase the functional diversity of the proteome but in disease situations might do more harm than good. Post-translational ... -
Potassium channels in behavioral brain disorders. Molecular mechanisms and therapeutic potential: A narrative review
(Journal article; Peer reviewed, 2023)Potassium channels (K+-channels) selectively control the passive flow of potassium ions across biological membranes and thereby also regulate membrane excitability. Genetic variants affecting many of the human K+-channels ... -
POU3f2 in human gliomas - Expression pattern and functional role
(Master thesis, 2014-06-02)Gliomas are tumors of the central nervous system (CNS). They are responsible for about 28% of all central nervous system tumors and for 80% of all malignant brain tumors. The most commonly used classification and grading ... -
Practical considerations for omics experiments in biomedical sciences
(Peer reviewed; Journal article, 2016)Modern analytical techniques provide an unprecedented insight to biomedical samples, allowing an in depth characterization of cells or body fluids, to the level of genes, transcripts, peptides, proteins, metabolites, or ... -
Preparing for an influenza pandemic: Re-evaluating the use of the whole inactivated virus vaccine formulation. –A comparison of the immune responses after intramuscular or intranasal immunization with an influenza H5N1 whole inactivated virus vaccine in a murine model.
(Master thesis, 2009-10-22)Influenza is a highly contagious respiratory disease which infects millions of people every year around the world. Influenza viruses undergo continuous antigen change and annual vaccination is an effective prophylactic ... -
Pretreatment of glioblastoma with bortezomib potentiates natural killer cell cytotoxicity through TRAIL/DR5 mediated apoptosis and prolongs animal survival
(Peer reviewed; Journal article, 2019-07-17)Background: Natural killer (NK) cells are potential effectors in anti-cancer immunotherapy; however only a subset potently kills cancer cells. Here, we examined whether pretreatment of glioblastoma (GBM) with the proteasome ... -
Prevalence and clinical correlates of insomnia in adults with attention-deficit hyperactivity disorder
(Peer reviewed; Journal article, 2017-08)Objective: To investigate the prevalence of insomnia in adults with Attention-deficit hyperactivity disorder (ADHD) and its association with clinical subtypes, current ADHD symptoms, and stimulant treatment. Method: We ... -
Propofol alleviates DNA damage induced by oxygen glucose deprivation and reperfusion via FoxO1 nuclear translocation in H9c2 cells
(Peer reviewed; Journal article, 2019-03-15)Ischemia/reperfusion (I/R) injury induces irreversible oxidative stress damage to the cardiac myocytes. Many studies have revealed that propofol alleviates the important organelle-mediated injury from oxidative stress in ... -
Propofol ameliorates H9c2 cells apoptosis induced by oxygen glucose deprivation and reperfusion injury via inhibiting high levels of mitochondrial fusion and fission
(Peer reviewed; Journal article, 2019-02-12)Background: The cardioprotective effect of propofol on ischemia-reperfusion injury (I/R injury) is partly due to suppressing apoptosis. Mitochondrial dynamics are also involved in apoptosis. Mitochondrial fusion and fission ... -
Protein expression profiling of plasma and lungs at different stages of metastatic development in a human triple negative breast cancer xenograft model.
(Peer reviewed; Journal article, 2019-05-01)The main objective of this study was to identify single proteins or protein networks that might be used as diagnostic biomarkers or for therapeutic purposes by evaluating the protein expression profiling of plasma and lungs ... -
Protein target highlights in CASP15: Analysis of models by structure providers
(Journal article; Peer reviewed, 2023)We present an in-depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how effectively ... -
Proteogenomic Analysis of Polymorphisms and Gene Annotation Divergences in Prokaryotes using a Clustered Mass Spectrometry-Friendly Database
(Peer reviewed; Journal article, 2011-01)Precise annotation of genes or open reading frames is still a difficult task that results in divergence even for data generated from the same genomic sequence. This has an impact in further proteomic studies, and also ... -
Proteoglycans contribute to the functional integrity of the glomerular endothelial cell surface layer and are regulated in diabetic kidney disease
(Journal article; Peer reviewed, 2021)All capillary endothelia, including those of the glomeruli, have a luminal cell surface layer (ESL) consisting of glycoproteins, glycolipids, proteoglycans (PGs) and glycosaminoglycans. Previous results have demonstrated ...