Blar i Department of Biomedicine på tittel
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thermo-msf-parser: An Open Source Java Library to Parse and Visualize Thermo Proteome Discoverer msf Files
(Peer reviewed; Journal article, 2011)The Thermo Proteome Discoverer program integrates both peptide identification and quantification into a single workflow for peptide-centric proteomics. Furthermore, its close integration with Thermo mass spectrometers has ... -
Thiabendazole Inhibits Glioblastoma Cell Proliferation and Invasion Targeting Mini-chromosome Maintenance Protein 2
(Journal article; Peer reviewed, 2022)Thiabendazole (TBZ), approved by the US Food and Drug Administration (FDA) for human oral use, elicits a potential anticancer activity on cancer cells in vitro and in animal models. Here, we evaluated the efficacy of TBZ ... -
A three dimensional visualisation approach to protein heavy-atom structure reconstruction
(Peer reviewed; Journal article, 2014-12-31)Background: A commonly recurring problem in structural protein studies, is the determination of all heavy atom positions from the knowledge of the central α-carbon coordinates. Results: We employ advances in virtual reality ... -
Three-dimensional nanofibrous sponges with aligned architecture and controlled hierarchy regulate neural stem cell fate for spinal cord regeneration
(Journal article; Peer reviewed, 2023)Background: Spinal cord injury (SCI) induces neuronal death and disrupts the nerve fiber bundles, which leads to severe neurological dysfunction and even permanent paralysis. A strategy combining biomimetic nanomaterial ... -
Time course of decompensation after angiotensin II and high-salt diet in Balb/CJ mice suggests pulmonary hypertension-induced cardiorenal syndrome
(Peer reviewed; Journal article, 2019-05-01)The genetic background of a mouse strain determines its susceptibility to disease. C57BL/6J and Balb/CJ are two widely used inbred mouse strains that we found react dramatically differently to angiotensin II and high-salt ... -
TNT-Induced Phagocytosis: Tunneling Nanotubes Mediate the Transfer of Pro-Phagocytic Signals From Apoptotic to Viable Cells
(Peer reviewed; Journal article, 2017-09)The exposure of phosphatidylserine (PS) on the surface membrane of apoptotic cells triggers the recruitment of phagocytic receptors and subsequently results in uptake by phagocytes. Here we describe how apoptotic cells can ... -
To hit or not to hit, that is the question -genome-wide structure-based druggability predictions for pseudomonas aeruginosa proteins
(Peer reviewed; Journal article, 2015-09-11)Pseudomonas aeruginosa is a Gram-negative bacterium known to cause opportunistic infections in immune-compromised or immunosuppressed individuals that often prove fatal. New drugs to combat this organism are therefore ... -
Toward understanding scarless skin wound healing and pathological scarring
(Peer reviewed; Journal article, 2019)The efficient healing of skin wounds is crucial for securing the vital barrier function of the skin, but pathological wound healing and scar formation are major medical problems causing both physiological and psychological ... -
Toxicity and tropism of oncolytic VSV vectors in glioblastoma gene therapy
(Master thesis, 2012-11-05)Glioblastoma multiforme is the most common and most fatal primary brain tumor in adults. Despite using advanced conventional therapeutic approaches like surgical resection, radiotherapy and chemotherapy only marginal ... -
Transcriptional and epigenetic mechanisms underlying astrocyte identity
(Peer reviewed; Journal article, 2019-03)Astrocytes play a significant role in coordinating neural development and provide critical support for the function of the CNS. They possess important adaptation capacities that range from their transition towards reactive ... -
Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells
(Peer reviewed; Journal article, 2015-01-09)Tunneling nanotubes (TNTs) are F-actin-based membrane tubes that form between cells in culture and in tissues. They mediate intercellular communication ranging from electrical signalling to the transfer of organelles. Here, ... -
Translational regulation in the adult brain: mediated by BDNF signalling, stress, and chronic antidepressant treatment
(Doctoral thesis, 2010-09-01)One of the most amazing features of the brain is its plasticity. This is a fundamental process by which the brain acquires information and makes the appropriate adaptive changes, a process that makes us able to think, feel, ... -
Trifluoperazine prolongs the survival of experimental brain metastases by STAT3-dependent lysosome membrane permeabilization
(Journal article; Peer reviewed, 2020)Brain metastasis is a major cause of mortality in melanoma patients. The blood-brain barrier (BBB) prevents most anti-tumor compounds from entering the brain, which significantly limits their use in the treatment of brain ... -
Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination
(Peer reviewed; Journal article, 2017-09-05)Background: Resistance to adjuvant radiotherapy is a major cause of treatment failure in patients with glioblastoma (GBM). Autophagy inhibitors have been shown to enhance the efficacy of radiotherapy for certain solid ... -
TRIM22 activates NF-κB signaling in glioblastoma by accelerating the degradation of IκBα
(Journal article; Peer reviewed, 2021)NF-κB signaling plays a critical role in tumor growth and treatment resistance in GBM as in many other cancers. However, the molecular mechanisms underlying high, constitutive NF-κB activity in GBM remains to be elucidated. ... -
TRIM56 promotes malignant progression of glioblastoma by stabilizing cIAP1 protein
(Journal article; Peer reviewed, 2022)Background The tripartite motif (TRIM) family of proteins plays a key role in the developmental growth and therapeutic resistance of many tumors. However, the regulatory mechanisms and biological functions of TRIM proteins ... -
Tryptophan and kynurenine pathway metabolites in neuropsychiatric disorders
(Doctoral thesis, 2024-05-21)Bakgrunn: Kynureninar er ei gruppe metabolittar av den kosthaldsavhengige aminosyra tryptofan (Trp) som er involverte i ei rekkje biologiske mekanismar, mellom anna inflammasjon og reguleringa av nevrotransmitteren glutamat. ... -
Tumor interstitial fluid formation, characterization, and clinical implications
(Peer reviewed; Journal article, 2015-05-26)The interstitium, situated between the blood and lymph vessels and the cells, consists of a solid or matrix phase and a fluid phase representing the tissue microenvironment. In the present review, we focus on the interstitial ... -
Tumor oxygenation - influence on mammary tumor growth, progression and response to chemotherapy
(Doctoral thesis, 2011-04-28) -
Tumor-associated macrophages in gliomas—basic insights and treatment opportunities
(Journal article; Peer reviewed, 2022)Glioma refers to a group of primary brain tumors which includes glioblastoma (GBM), astrocytoma and oligodendroglioma as major entities. Among these, GBM is the most frequent and most malignant one. The highly infiltrative ...