Browsing Department of Biomedicine by Title
Now showing items 256-275 of 742
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EXT proteins: Role in heparan sulfate Assembly and in Tumor biology
(Doctoral thesis, 2018-08-24)The exostosin family of proteins is necessary for heparan sulfate biosynthesis. Heparan sulfate polysaccharide biosynthesis is one of several different forms of proteinglycosylation processes that take place in the Golgi ... -
The extostosin family: Proteins with many functions
(Peer reviewed; Journal article, 2014-04)Heparan sulfates are complex sulfated molecules found in abundance at cell surfaces and in the extracellular matrix. They bind to and influence the activity of a variety of molecules like growth factors, proteases and ... -
Extrasynaptic NMDA receptors on rod pathway amacrine cells: molecular composition, activation, and signaling
(Peer reviewed; Journal article, 2019)In the rod pathway of the mammalian retina, axon terminals of glutamatergic rod bipolar cells are presynaptic to AII and A17 amacrine cells in the inner plexiform layer. Recent evidence suggests that both amacrines express ... -
Familial co-aggregation of attention-deficit/ hyperactivity disorder and autoimmune diseases: a cohort study based on Swedish population-wide registers
(Journal article; Peer reviewed, 2021)Background Attention-deficit/hyperactivity disorder (ADHD) has been associated with several autoimmune diseases (AD), both within individuals and across relatives, implying common underlying genetic or environmental factors ... -
Fast hyperbaric decompression after heliox saturation altered the brain proteome in rats
(Peer reviewed; Journal article, 2017-10-04)Better understanding of the physiological mechanisms and neurological symptoms involved in the development of decompression sickness could contribute to improvements of diving procedures. The main objective of the present ... -
Feasibility of deep learning-based tumor segmentation for target delineation and response assessment in grade-4 glioma using multi-parametric MRI
(Journal article; Peer reviewed, 2023)Background Tumor burden assessment is essential for radiation therapy (RT), treatment response evaluation, and clinical decision-making. However, manual tumor delineation remains laborious and challenging due to ... -
Fibroblast EXT1-Levels Influence Tumor Cell Proliferation and Migration in Composite Spheroids
(Peer reviewed; Journal article, 2012-07-25)Background: Stromal fibroblasts are important determinants of tumor cell behavior. They act to condition the tumor microenvironment, influence tumor growth, support tumor angiogenesis and affect tumor metastasis. Heparan ... -
Fibroblast α11β1 Integrin Regulates Tensional Homeostasis in Fibroblast/A549 Carcinoma Heterospheroids
(Peer reviewed; Journal article, 2014-07-30)We have previously shown that fibroblast expression of α11β1 integrin stimulates A549 carcinoma cell growth in a xenograft tumor model. To understand the molecular mechanisms whereby a collagen receptor on fibroblast can ... -
Filamin A binds to CCR2B and regulates its internalization
(Peer reviewed; Journal article, 2010-08-17)The chemokine (C-C motif) receptor 2B (CCR2B) is one of the two isoforms of the receptor for monocyte chemoattractant protein-1 (CCL2), the major chemoattractant for monocytes, involved in an array of chronic inflammatory ... -
Filamin A-Hinge Region 1-EGFP: A Novel Tool for Tracking the Cellular Functions of Filamin A in Real-Time
(Peer reviewed; Journal article, 2012-08-01)Background: Filamin A (FLNa) is an actin-crosslinking protein necessary for stabilizing the cell surface, organizing protrusive activity and for promoting efficient cellular translocation. Recently, our group demonstrated ... -
The Final Maturation State of β-actin Involves N-terminal Acetylation by NAA80, not N-terminal Arginylation by ATE1
(Journal article; Peer reviewed, 2022)Actin is a hallmark protein of the cytoskeleton in eukaryotic cells, affecting a range of cellular functions. Actin dynamics is regulated through a myriad of actin-binding proteins and post-translational modifications. The ... -
The flavagline FL3 interferes with the association of Annexin A2 with the eIF4F initiation complex and transiently stimulates the translation of annexin A2 mRNA
(Journal article; Peer reviewed, 2023-05-12)Introduction: Annexin A2 (AnxA2) plays a critical role in cell transformation, immune response, and resistance to cancer therapy. Besides functioning as a calcium- and lipidbinding protein, AnxA2 also acts as an mRNA-binding ... -
Flexible Players within the Sheaths: The Intrinsically Disordered Proteins of Myelin in Health and Disease
(Journal article; Peer reviewed, 2020)Myelin ensheathes selected axonal segments within the nervous system, resulting primarily in nerve impulse acceleration, as well as mechanical and trophic support for neurons. In the central and peripheral nervous systems, ... -
Flow cytometry-based functional selection of RNA interference triggers for efficient epi-allelic analysis of therapeutic targets
(Peer reviewed; Journal article, 2014-06-21)Background: The dose-response relationship is a fundamental pharmacological parameter necessary to determine therapeutic thresholds. Epi-allelic hypomorphic analysis using RNA interference (RNAi) can similarly correlate ... -
Fluid transport from the dental pulp revisited.
(Journal article; Peer reviewed, 2020-10)In the dental pulp surrounded by rigid dentinal walls, an increase in fluid volume will be followed by a rapid increase in interstitial fluid pressure. To maintain pressure homeostasis, a fluid drainage system is required. ... -
Forward genetics and functional analysis highlight Itga11 as a modulator of murine psoriasiform dermatitis
(Journal article; Peer reviewed, 2023)Psoriasis is a chronic inflammatory skin condition. Repeated epicutaneous application of Aldara® (imiquimod) cream results in psoriasiform dermatitis in mice. The Aldara®-induced psoriasiform dermatitis (AIPD) mouse model ... -
Fractional anisotropy shows differential reduction in frontal-subcortical fiber bundles - A longitudinal MRI study of 76 middle-aged and older adults
(Peer reviewed; Journal article, 2015-05-15)Motivated by the frontal- and white matter (WM) retrogenesis hypotheses and the assumptions that fronto-striatal circuits are especially vulnerable in normal aging, the goal of the present study was to identify fiber bundles ... -
Fragment screening using biolayer interferometry reveals ligands targeting the SHP-motif binding site of the AAA+ ATPase p97
(Journal article; Peer reviewed, 2022)Biosensor techniques have become increasingly important for fragment-based drug discovery during the last years. The AAA+ ATPase p97 is an essential protein with key roles in protein homeostasis and a possible target for ... -
Function and regulation of phenylalanine and tyrosine hydroxylases from human and Caenorhabditis elegans. With focus in evolutionary aspects and development of new therapies
(Doctoral thesis, 2010-06-11)The family of the aromatic amino acid hydroxylases (AAAH) is well studied in mammals. It includes four members, i.e. phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH) and the tryptophan hydroxylases (TPH1 and 2). ... -
A function of profilin in force generation during malaria parasite motility that is independent of actin binding
(Journal article; Peer reviewed, 2020)During transmission of malaria-causing parasites from mosquito to mammal, Plasmodium sporozoites migrate at high speed within the skin to access the bloodstream and infect the liver. This unusual gliding motility is based ...