Now showing items 292-311 of 705

    • Glioblastomas with primitive neuronal component harbor a distinct methylation and copy‑number profle with inactivation of TP53, PTEN, and RB1 

      Suwala, Abigail K.; Stichel, Damian; Schrimpf, Daniel; Maas, Sybren L. N.; Sill, Martin; Dohmen, Hildegard; Banan, Rouzbeh; Reinhardt, Annekathrin; Sievers, Philipp; Hinz, Felix; Blattner-Johnson, Mirjam; Hartmann, Christian; Schweizer, Leonille; Boldt, Henning B.; Kristensen, Bjarne Winther; Schittenhelm, Jens; Wood, Matthew D.; Chotar, Guillaume; Bjerkvig, Rolf; Das, Anirban; Tabori, Uri; Hasselblatt, Martin; Korshunov, Andrey; Abdullaev, Zied; Quezado, Martha; Aldape, Kenneth; Harter, Patrick N.; Snuderl, Matija; Hench, Jürgen; Frank, Stephan; Acker, Till; Brandner, Sebastian; Winkler, Frank; Wesseling, Pieter; Pfister, Stefan M.; Reuss, David E.; Wick, Wolfgang; von Deimling, Andreas; Jones, David T. W.; Sahm, Felix (Journal article; Peer reviewed, 2021)
      Glioblastoma IDH-wildtype presents with a wide histological spectrum. Some features are so distinctive that they are considered as separate histological variants or patterns for the purpose of classification. However, these ...
    • GSK3α and GSK3β Phosphorylate Arc and Regulate its Degradation 

      Gozdz, Agata; Nikolaienko, Oleksii; Urbanska, Malgorzata; Cymerman, Iwona; Sitkiewicz, Ewa; Blazejczyk, Magdalena; Dadlez, Michal; Bramham, Clive R.; Jaworski, Jacek (Peer reviewed; Journal article, 2017-06-16)
      The selective and neuronal activity-dependent degradation of synaptic proteins appears to be crucial for long-term synaptic plasticity. One such protein is activity-regulated cytoskeleton-associated protein (Arc), which ...
    • HAMLET forms annular oligomers when deposited with phoshpolipid monolayers 

      Baumann, Anne; Gjerde, Anja Underhaug; Ying, Ming; Svanborg, Catharina; Holmsen, Holm A.; Glomm, Wilhelm; Martinez, Aurora; Halskau, Øyvind (Peer reviewed; Journal article, 2012-04)
      Recently, the anticancer activity of human α-lactalbumin made lethal to tumor cells (HAMLET) has been linked to its increased membrane affinity in vitro, at neutral pH, and ability to cause leakage relative to the inactive ...
    • HAMLET interacts with lipid membranes and perturbs their structure and integrity 

      Mossberg, Ann-Kristin; Puchades, Maja; Halskau, Øyvind; Baumann, Anne; Lanekoff, Ingela; Chao, Yinxia; Martinez, Aurora; Svanborg, Catharina; Karlsson, Roger (Peer reviewed; Journal article, 2010-01-23)
      Background Cell membrane interactions rely on lipid bilayer constituents and molecules inserted within the membrane, including specific receptors. HAMLET (human α-lactalbumin made lethal to tumor cells) is a tumoricidal ...
    • Health-related quality of life in elderly patients hospitalized with chronic heart failure 

      Erceg, Predrag; Despotovic, Nebosja; Milosevic, Drogoslav P.; Soldatovic, Ivan; Zdravkovic, Sanja; Tomic, Snezana; Markovic, Ivana; Mihajlovic, Gordana; Brajovic, Milan D.; Bojovic, Ognjen; Potic, Bojana; Davidovic, Mladen (Peer reviewed; Journal article, 2013-11-15)
      Background: Chronic heart failure is a very common condition in the elderly, characterized not only by high mortality rates, but also by a strong impact on health-related quality of life (HRQOL). Previous studies of HRQOL ...
    • Healthy kidney segmentation in the dce-mr images using a convolutional neural network and temporal signal characteristics 

      Klepaczko, Artur; Eikefjord, Eli Nina; Lundervold, Arvid (Journal article; Peer reviewed, 2021)
      Quantification of renal perfusion based on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) requires determination of signal intensity time courses in the region of renal parenchyma. Thus, selection of voxels ...
    • The Heart and a Fibrotic Interstitium 

      Sagvaag, Vivian (Master thesis, 2009-05-29)
      Several acute and chronic diseases disposes for myocardial oedema and fibrosis, leading to impaired cardiac function, presumably as a result of an increased chamber stiffness. Mechanisms and adverse effects of both oedema ...
    • Heparan sulfate dependent binding of plasmatic von Willebrand factor to blood circulating melanoma cells attenuates metastasis 

      Wang, Yuanyuan; Liu, Xiaobo; Obser, Tobias; Bauer, Alexander T.; Heyes, Martin; Starzonek, Sarah; Zulal, Mina; Opitz, Karena; Ott, Leonie; Riethdorf, Sabine; Lange, Tobias; Pantel, Klaus; Bendas, Gerd; Schneider, Stefan W.; Gullberg, Marion Kusche; Gorzelanny, Christian (Journal article; Peer reviewed, 2022)
      Heparan sulfate (HS), a highly negatively charged glycosaminoglycan, is ubiquitously present in all tissues and also exposed on the surface of mammalian cells. A plethora of molecules such as growth factors, cytokines or ...
    • Herpes Simplex Virus Type 1 Neuronal Infection Triggers the Disassembly of Key Structural Components of Dendritic Spines 

      Acuña-Hinrichsen, Francisca; Covarrubias-Pinto, Adriana; Ishizuka, Yuta; Stolzenbach, María Francisca; Martin, Carolina; Salazar, Paula; Castro, Maite A.; Bramham, Clive Raymond Evjen; Otth, Carola (Journal article; Peer reviewed, 2021)
      Herpes simplex virus type 1 (HSV-1) is a widespread neurotropic virus. Primary infection of HSV-1 in facial epithelium leads to retrograde axonal transport to the central nervous system (CNS) where it establishes latency. ...
    • HIDEA syndrome is caused by biallelic, pathogenic, rare or founder P4HTM variants impacting the active site or the overall stability of the P4H-TM protein 

      Kraatari-Tiri, Minna; Soikkonen, Leila; Myllykoski, Matti Aukusti; Jamshidi, Yalda; Karimiani, Ehsan G.; Komulainen-Ebrahim, Jonna; Kallankari, Hanna; Mignot, Cyril; Depienne, Christel; Keren, Boris; Nougues, Marie-Christine; Alsahlawi, Zahra; Romito, Antonio; Martini, Javier; Toosi, Mehran B.; Carroll, Christopher J.; Tripolszki, Kornelia; Bauer, Peter; Uusimaa, Johanna; Bertoli-Avella, Aida M.; Koivunen, Peppi; Rahikkala, Elisa (Journal article; Peer reviewed, 2022)
      HIDEA syndrome is caused by biallelic pathogenic variants in P4HTM. The phenotype is characterized by muscular and central hypotonia, hypoventilation including obstructive and central sleep apneas, intellectual disability, ...
    • High-affinity anti-Arc nanobodies provide tools for structural and functional studies 

      Markusson, Sigurbjörn; Hallin, Erik Ingmar; Bustad, Helene J.; Raasakka, Arne; Xu, Ju; Muruganandam, Gopinath; Loris, Remy; Martinez, Aurora; Bramham, Clive Raymond Evjen; Kursula, Petri (Journal article; Peer reviewed, 2022)
      Activity-regulated cytoskeleton-associated protein (Arc) is a multidomain protein of retroviral origin with a vital role in the regulation of synaptic plasticity and memory formation in mammals. However, the mechanistic ...
    • High-dimensional immunotyping of tumors grown in obese and non-obese mice 

      Wogsland, Cara Ellen; Lien, Hilde Eide; Pedersen, Line; Hanjra, Pahul; Grøndal, Sturla Magnus; Brekken, Rolf A; Lorens, James Bradley; Halberg, Nils Henrik (Journal article; Peer reviewed, 2021)
      Obesity is a disease characterized by chronic low-grade systemic inflammation and has been causally linked to the development of 13 cancer types. Several studies have been undertaken to determine whether tumors evolving ...
    • High-Dimensional Phenotyping Identifies Age-Emergent Cells in Human Mammary Epithelia 

      Pelissier, Fanny; Schapiro, Denis; Chang, Hang; Borowsky, Alexander D.; Lee, Jonathan K.; Parvin, Bahram; Stampfer, Martha R.; LaBarge, Mark A.; Bodenmiller, Bernd; Lorens, James B. (Peer reviewed; Journal article, 2018-04)
      Aging is associated with tissue-level changes in cellular composition that are correlated with increased susceptibility to disease. Aging human mammary tissue shows skewed progenitor cell potency, resulting in diminished ...
    • High-resolution structures of malaria parasite actomyosin and actin filaments 

      Vahokoski, Juha; Calder, Lesley J.; Moreno, Andrea Johana Lopez; Molloy, Justin E.; Kursula, Inari; Rosenthal, Peter B. (Journal article; Peer reviewed, 2022-04-04)
      Malaria is responsible for half a million deaths annually and poses a huge economic burden on the developing world. The mosquito-borne parasites (Plasmodium spp.) that cause the disease depend upon an unconventional ...
    • High-salt diet causes osmotic gradients and hyperosmolality in skin without affecting interstitial fluid and lymph 

      Nikpey Esfahlan, Elham; Karlsen, Tine Veronica; Rakova, Natalia; Titze, Jens M.; Tenstad, Olav; Wiig, Helge (Peer reviewed; Journal article, 2017-04)
      The common notion is that the body Na+ is maintained within narrow limits for fluid and blood pressure homeostasis. Several studies have, however, shown that considerable amounts of Na+ can be retained or removed from the ...
    • Histological and bacteriological changes in intestine of beluga (Huso huso) following ex vivo exposure to bacterial strains 

      Salma, Wahida; Zhou, Zhigang; Wang, Wenwan; Askarian, Fatemeh; Kousha, Armin; Ebrahimi, Maryam Tajabadi; Myklebust, Reidar; Ringø, Einar (Peer reviewed; Journal article, 2011-04-04)
      In the present study the intestinal sac method (ex vivo) was used to evaluate the interactions between lactic acid bacteria and staphylococci in the gastrointestinal (GI) tract of beluga (Huso huso). The distal intestine ...
    • How Does Protein Zero Assemble Compact Myelin? 

      Raasakka, Arne; Kursula, Petri (Journal article; Peer reviewed, 2020-08)
      Myelin protein zero (P0), a type I transmembrane protein, is the most abundant protein in peripheral nervous system (PNS) myelin—the lipid-rich, periodic structure of membrane pairs that concentrically encloses long axonal ...
    • How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study Using N-Myristoyltransferases as a Model System 

      Kersten, Christian; Fleischer, Edmond; Kehrein, Josef; Borek, Christoph; Jaenicke, Elmar; Sotriffer, Christoph; Brenk, Ruth (Peer reviewed; Journal article, 2020)
      A model system of two related enzymes with conserved binding sites, namely N-myristoyltransferase from two different organisms, was studied to decipher the driving forces that lead to selective inhibition in such cases. ...
    • Human blood serum proteome changes after 6 hours of sleep deprivation at night 

      Bjørkum, Alvhild Alette; Duran, Ana Carasco; Berven, Frode Steingrimsen; Roy, Dola Sinha; Rosendahl, Karen; Birkeland, Even; Stuhr, Linda Elin Birkhaug (Journal article; Peer reviewed, 2021)
      Background The aim of this study was to discover significantly changed proteins in human blood serum after loss of 6 h sleep at night. Furthermore, to reveal affected biological process- and molecular function categories ...
    • Human myelin protein P2: from crystallography to time-lapse membrane imaging and neuropathy-associated variants 

      Uusitalo, Maiju; Klenow, Martin Berg; Laulumaa, Saara; Blakeley, Matthew P.; Simonsen, Adam Cohen; Ruskamo, Salla; Kursula, Petri (Journal article; Peer reviewed, 2021)
      Peripheral myelin protein 2 (P2) is a fatty acid-binding protein expressed in vertebrate peripheral nervous system myelin, as well as in human astrocytes. Suggested functions of P2 include membrane stacking and lipid ...