Blar i Department of Biomedicine på tittel

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    • Lack of collagen XVIII leads to lipodystrophy and perturbs hepatic glucose and lipid homeostasis 

      Petäistö, Tiina; Vicente, David; Mäkelä, Kari A; Finnilä, Mikko A; Miinalainen, Ilkka; Koivunen, Jarkko; Izzi, Valerio; Aikio, Mari; Karppinen, Sanna-Maria; Davarajan, Raman; Thevenot, Jerome; Herzig, Karl-Heinz; Heljasvaara, Ritva Leena; Pihlajaniemi, Taina (Journal article; Peer reviewed, 2020)
      Liver and adipose tissues play important roles in the regulation of systemic glucose and lipid metabolism. Extracellular matrix synthesis and remodelling are significantly altered in these tissues in obesity and type 2 ...

    • Lack of functional normalisation of tumour vessels following anti-angiogenic therapy in glioblastoma 

      Obad, Nina; Espedal, Heidi; Jirík, Radovan; Sakariassen, Per Øystein; Rygh, Cecilie Brekke; Lund-Johansen, Morten; Taxt, Torfinn; Niclou, Simone Pierrette; Bjerkvig, Rolf; Keunen, Olivier (Peer reviewed; Journal article, 2017)
      Neo-angiogenesis represents an important factor for the delivery of oxygen and nutrients to a growing tumour, and is considered to be one of the main pathodiagnostic features of glioblastomas (GBM). Anti-angiogenic therapy ...

    • Lactate dehydrogenases promote glioblastoma growth and invasion via a metabolic symbiosis 

      Guyon, Joris; Fernandez-Moncada, Ignacio; Larrieu, Claire M; Bouchez, Cyrielle L; Pagano Zottola, Antonio C; Galvis, Johanna; Chouleur, Tiffanie; Burban, Audrey; Joseph, Kevin; Ravi, Vidhya M; Espedal, Heidi; Røsland, Gro Vatne; Daher, Boutaina; Barre, Aurélien; Dartigues, Benjamin; Karkar, Slim; Rudewicz, Justine; Romero-Garmendia, Irati; Klink, Barbara; Grützmann, Konrad; Derieppe, Marie-Alix; Molinié, Thibaut; Obad, Nina; Léon, Céline; Seano, Giorgio; Miletic, Hrvoje; Heiland, Dieter Henrik; Marsicano, Giovanni; Nikolski, Macha; Bjerkvig, Rolf; Bikfalvi, Andreas; Daubon, Thomas (Journal article; Peer reviewed, 2022)
      Lactate is a central metabolite in brain physiology but also contributes to tumor development. Glioblastoma (GB) is the most common and malignant primary brain tumor in adults, recognized by angiogenic and invasive growth, ...

    • The laminin response in inflammatory bowel disease: Protection or malignancy? 

      Spenle, Caroline; Lefebvre, Olivier; Lacroute, Joel; Mechine-Neuville, Agnes; Barreau, Frederick; Blottiere, Herve M; Duclos, Bernard; Arnold, Christiane; Hussenet, Thomas; Hemmerle, Joseph; Gullberg, Donald; Kedinger, Michele; Sorokin, Lydia; Orend, Gertraud; Simon-Assmann, Patricia (Peer reviewed; Journal article, 2014-10-27)
      Laminins (LM), basement membrane molecules and mediators of epithelial-stromal communication, are crucial in tissue homeostasis. Inflammatory Bowel Diseases (IBD) are multifactorial pathologies where the microenvironment ...

    • Leukocyte transmigration into tissue-engineered constructs is influenced by endothelial cells through Toll-like receptor signaling 

      Bartaula-Brevik, Sushma; Pedersen, Torbjorn Østvik; Blois, Anna L; Papadakou, Panagiota; Finne-Wistrand, Anna; Xue, Ying; Bolstad, Anne Isine; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2014-12-20)
      Introduction Inflammation plays a crucial role in tissue regeneration, wound healing, and the success of tissue-engineered constructs. The aim of this study was to investigate the influence of human umbilical vein endothelial ...

    • The life cycle and enigmatic egress of coronaviruses 

      Prydz, Kristian; Saraste, Jaakko (Journal article; Peer reviewed, 2022)
      There has been considerable recent interest in the life cycle of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), the causative agent of the Covid-19 pandemic. Practically every step in CoV replication—from ...

    • Lipopolysaccharide induces filtrate leakage from renal tubular lumina into the interstitial space via a proximal tubular Toll-like receptor 4–dependent pathway and limits sensitivity to fluid therapy in mice 

      Nakano, Daisuke; Kitada, Kento; Wan, Ningning; Zhang, Yahua; Wiig, Helge; Wararat, Kittikulsuth; Yanagita, Motoko; Lee, Syann; Jia, Lin; Titze, Jens M.; Nishiyama, Akira (Journal article; Peer reviewed, 2019-12-16)
      Sustained oliguria during fluid resuscitation represents a perplexing problem in patients undergoing therapy for septic acute kidney injury. Here, we tested whether lipopolysaccharide induces filtrate leakage from the ...

    • LncRNAs Predicted to Interfere With the Gene Regulation Activity of miR-637 and miR-196a-5p in GBM 

      Zheng, Jingfang; Su, Zhiying; Kong, Yang; Lin, Qingping; Liu, Hongli; Wang, Yanlong; Wang, Jian (Journal article; Peer reviewed, 2020)
      Rigorous molecular characterization of biological systems has uncovered a variety of gene variations underlying normal and disease states and a remarkable complexity in the forms of RNA transcripts that exist. A recent ...

    • Long-term consumption of an obesogenic high fat diet prior to ischemia-reperfusion mediates cardioprotection via Epac1-dependent signaling 

      Edland, Fridtjov; Wergeland, Anita; Kopperud, Reidun Kristin; Åsrud, Kathrine Sivertsen; Hoivik, Erling A; Witsø, Solveig Lund; Æsøy, Reidun; Madsen, L; Kristiansen, K.; Bakke, Marit; Doskeland, Stein Ove; Jonassen, Anne K (Peer reviewed; Journal article, 2016-11-28)
      Background: Obesity is still considered a risk factor for cardiovascular disease, although more recent knowledge also suggests obesity to be associated with reduced morbidity and mortality - the “obesity paradox”. This ...

    • Long-term treatment with valganciclovir improves lentiviral suicide gene therapy of glioblastoma 

      Hossain, Jubayer; Latif, Md Abdul; Ystaas, Lars Andreas Rømo; Ninzima, Sandra; Riecken, Kristoffer; Muller, Arnaud; Azuaje, Fransisco; Vareecal Joseph, Justin; Talasila, Krishna Mukharji; Ghimire, Jiwan; Fehse, Boris; Bjerkvig, Rolf; Miletic, Hrvoje (Peer reviewed; Journal article, 2019)
      Background: Suicide gene therapy for malignant gliomas has shown encouraging results in the latest clinical trials. However, prodrug application was most often restricted to short-term treatment (14 days), especially when ...

    • Loss of COPZ1 induces NCOA4 mediated autophagy and ferroptosis in glioblastoma cell lines 

      Zhang, Yulin; Kong, Yang; Ma, Yuan; Ni, Shilei; Wikerholmen, Tobias Espedal; Xi, Kaiyan; Zhao, Feihu; Zhao, Zhimin; Wang, Junpeng; Huang, Bin; Chen, Anjing; Yao, Zhong; Han, Mingzhi; Feng, Zichao; Hu, Yaotian; Thorsen, Frits; Wang, Jiang; Li, Xingang (Journal article; Peer reviewed, 2021)
      Dysregulated iron metabolism is a hallmark of many cancers, including glioblastoma (GBM). However, its role in tumor progression remains unclear. Herein, we identified coatomer protein complex subunit zeta 1 (COPZ1) as a ...

    • Loss of N-terminal acetyltransferase A activity induces thermally unstable ribosomal proteins and increases their turnover in Saccharomyces cerevisiae 

      Guzman, Ulises H.; Aksnes, Henriette; Ree, Rasmus; Krogh, Nicolai; Jakobsson, Magnus; Jensen, Lars J.; Arnesen, Thomas; Olsen, Jesper V. (Journal article; Peer reviewed, 2023)
      Protein N-terminal (Nt) acetylation is one of the most abundant modifications in eukaryotes, covering ~50-80 % of the proteome, depending on species. Cells with defective Nt-acetylation display a wide array of phenotypes ...

    • Loss or mislocalization of aquaporin-4 affects diffusion properties and intermediary metabolism in gray matter of mice 

      Pavlin, Tina; Nagelhus, Erlend Arnulf; Brekken, Christian; Eyjolfsson, Elvar M.; Thoren, Anna; Haraldseth, Olav; Sonnewald, Ursula; Ottersen, Ole Petter; Håberg, Asta (Peer reviewed; Journal article, 2017-01)
      The first aim of this study was to determine how complete or perivascular loss of aquaporin-4 (AQP4) water channels affects membrane permeability for water in the mouse brain grey matter in the steady state. Time-dependent ...

    • Lowering of tumor interstitial fluid pressure reduces tumor cell proliferation in a xenograft tumor model 

      Hofmann, Matthias; Guschel, Maike; Bernd, August; Bereiter-Hahn, Jürgen; Kaufmann, Robert; Tandi, Christa; Wiig, Helge; Kippenberger, Stefan (Peer reviewed; Journal article, 2006-02)
      High tumor interstitial fluid pressure (TIFP) is a characteristic of most solid tumors. TIFP may hamper adequate uptake of macromolecular therapeutics in tumor tissue. In addition, TIFP generates mechanical forces affecting ...

    • LTP mechanisms in the dentate gyrus in vivo: BDNF signaling, translation control, and gene function 

      Kanhema, Tambudzai (Doctoral thesis, 2007-03-30)

    • Machine learning applications in proteomics research: How the past can boost the future 

      Kelchtermans, Pieter; Bittremieux, Wout; De Grave, Kurt; Degroeve, S; Ramon, Jan; Laukens, Kris; Valkenborg, Dirk; Barsnes, Harald; Martens, Lennart (Peer reviewed; Journal article, 2014)
      Machine learning is a subdiscipline within artificial intelligence that focuses on algorithms that allow computers to learn solving a (complex) problem from existing data. This ability can be used to generate a solution ...

    • Mammalian CSAD and GADL1 have distinct biochemical properties and patterns of brain expression 

      Winge, Ingeborg; Teigen, Knut; Fossbakk, Agnete; Mahootchi, Elaheh; Kleppe, Rune; Sköldberg, Filip; Kämpe, Olle; Haavik, Jan (Peer reviewed; Journal article, 2015-11)
      Variants in the gene encoding the enzyme glutamic acid decarboxylase like 1 (GADL1) have been associated with response to lithium therapy. Both GADL1 and the related enzyme cysteine sulfinic acid decarboxylase (CSAD) have ...

    • A map of metabolic phenotypes in patients with myalgic encephalomyelitis/chronic fatigue syndrome 

      Hoel, Fredrik; Hoel, August; Pettersen, Ina Katrine Nitschke; Rekeland, Ingrid Gurvin; Risa, Kristin; Alme, Kine; Sørland, Kari; Fosså, Alexander; Lien, Katarina; Herder, Ingrid; Thurmer, Hanne; Gotaas, Merethe Otelie Eide; Schäfer, Christoph; Berge, Rolf K.; Sommerfelt, Kristian; Marti, Hans Peter; Dahl, Olav; Mella, Olav; Fluge, Øystein; Tronstad, Karl Johan (Journal article; Peer reviewed, 2021)
      Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease usually presenting after infection. Emerging evidence supports that energy metabolism is affected in ME/CFS, but a unifying metabolic ...

    • Marine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin to Kill Leukemia Cells, but not Cardiomyocytes 

      Oftedal, Linn Silje Wathne; Selheim, Frode; Wahlsten, Matti; Sivonen, Kaarina; Døskeland, Stein Ove; Herfindal, Lars (Peer reviewed; Journal article, 2010-10-14)
      The potential of marine benthic cyanobacteria as a source of anticancer drug candidates was assessed in a screen for induction of cell death (apoptosis) in acute myeloid leukemia (AML) cells. Of the 41 marine cyanobacterial ...

    • Mass spectrometry-based proteomics of human cerebrospinal fluid. Biomarker discovery and verification in multiple sclerosis 

      Vethe, Heidrun (Master thesis, 2012-06-01)
      The main focus of this study was to use mass spectrometry-based proteomics to study protein abundance in cerebrospinal fluid (CSF) to reveal proteins that could serve as biomarker candidates in multiple sclerosis (MScl). ...