Blar i Department of Biomedicine på tittel
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Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy
(Peer reviewed; Journal article, 2019-09-24)The exchange proteins directly activated by cAMP 1 and 2 (Epac1 and Epac2) are expressed in a cell specific manner in the liver, but their biological functions in this tissue are poorly understood. The current study was ... -
The microenvironment in human ovarian carcinoma - characterization through proteomic analysis of tissue interstitial fluid
(Doctoral thesis, 2013-10-11)The interstitial fluid of tissues and that of tumors in particular, represents the secretome and is thus a valuable source of tissue-specific proteins. The differential expression of proteins that are secreted in tumor ... -
MicroRNA Regulation of the Synaptic Plasticity-Related Gene Arc
(Peer reviewed; Journal article, 2012-07-26)Expression of activity-regulated cytoskeleton associated protein (Arc) is crucial for diverse types of experience-dependent synaptic plasticity and long-term memory in mammals. However, the mechanisms governing Arc-specific ... -
Microsphere cytometry to interrogate microenvironment-dependent cell signaling
(Journal article; Peer reviewed, 2017)Microenvironmental cues comprising surface-mediated and soluble factors control cellular signaling mechanisms underlying normal cellular responses that define homeostatic and diseased cell states. In order to measure cell ... -
Mitochondrial DNA depletion in sporadic inclusion body myositis
(Peer reviewed; Journal article, 2019)Sporadic inclusion body myositis (sIBM) is a late onset disorder of unkown aetiology. Mitochondrial changes such as cytochrome oxidase deficient fibres are a well recognised feature and mitochondrial DNA (mtDNA) deletions ... -
Modelling cellular signal communication mediated by phosphorylation dependent interaction with 14-3-3 proteins
(Peer reviewed; Journal article, 2014-01-03)The 14-3-3 proteins are important effectors of Ser/Thr phosphorylation in eukaryotic cells. Using mathematical modelling we investigated the roles of these proteins as effectors in signalling pathways that involve ... -
Modulation of the Ago2-Associated microRNA Induced Silencing Complex during Long-Term Potentiation in the Rat Dentate Gyrus in Vivo
(Master thesis, 2012-05-30)Synaptic plasticity is defined as the ability of a neuronal synapse to change in strength, and is believed to be the basis of learning and memory. An example of synaptic plasticity, by far the most studied, is long-term ... -
Molecular basis for N-terminal acetylation by human NatE and its modulation by HYPK
(Journal article; Peer reviewed, 2020-02)The human N-terminal acetyltransferase E (NatE) contains NAA10 and NAA50 catalytic, and NAA15 auxiliary subunits and associates with HYPK, a protein with intrinsic NAA10 inhibitory activity. NatE co-translationally acetylates ... -
Molecular composition and function of integrin-based collagen glues—Introducing COLINBRIs
(Peer reviewed; Journal article, 2014-08)Background: Despite detailed knowledge about the structure and signaling properties of individual collagen receptors, much remains to be learned about how these receptors participate in linking cells to fibrillar collagen ... -
Molecular pathways of mitochondria transfer in Glioblastoma cells
(Master thesis, 2024-06-03)Glioblastoma (GBM) is a malignant brain tumor and the most aggressive form of brain cancer in adults. The aggressive nature and invasive properties of GBM cells contribute to the poor prognosis and increased rate of ... -
Molecular structure and function of myelin protein P0 in membrane stacking
(Peer reviewed; Journal article, 2019)Compact myelin forms the basis of nerve insulation essential for higher vertebrates. Dozens of myelin membrane bilayers undergo tight stacking, and in the peripheral nervous system, this is partially enabled by myelin ... -
Monoamine synthesis in neurometabolic disorders affecting catecholaminergic functioning: biochemical mechanisms and treatment implications
(Doctoral thesis, 2024-02-14)Løpet av de siste 100 år er det oppdaget hundrevis av arvelige metabolske forstyrrelser. Slike tilstander har ofte recessiv Mendelsk arv og kalles også medfødte metabolismefeil. Symptomene debuterer vanligvis like etter ... -
Monte Carlo vs. Pencil Beam based optimization of stereotactic lung IMRT
(Peer reviewed; Journal article, 2009-12-12)Background: The purpose of the present study is to compare finite size pencil beam (fsPB) and Monte Carlo (MC) based optimization of lung intensity-modulated stereotactic radiotherapy (lung IMSRT). Materials and methods: ... -
Morphological properties of the axon initial segment-like process of AII amacrine cells in the rat retina
(Journal article; Peer reviewed, 2021)Signal processing within the retina is generally mediated by graded potentials, whereas output is conveyed by action potentials transmitted along optic nerve axons. Among retinal neurons, amacrine cells seem to be an ... -
The mosaic of AII amacrine cell bodies in rat retina is indistinguishable from a random distribution
(Journal article; Peer reviewed, 2022)The vertebrate retina contains a large number of different types of neurons that can be distinguished by their morphological properties. Assuming that no location should be without a contribution from the circuitry and ... -
A multi-layer perceptron network for perfusion parameter estimation in DCE-MRI studies of the healthy kidney
(Journal article; Peer reviewed, 2020)Background: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is an imaging technique which helps in visualizing and quantifying perfusion—one of the most important indicators of an organ’s state. This paper ... -
Multi-Level Communication of Human Retinal Pigment Epithelial Cells via Tunneling Nanotubes
(Peer reviewed; Journal article, 2012-03-22)Background: Tunneling nanotubes (TNTs) may offer a very specific and effective way of intercellular communication. Here we investigated TNTs in the human retinal pigment epithelial (RPE) cell line ARPE-19. Morphology of ... -
Multi-national Gene Expression Profiling of Oral Squamous Cell Carcinomas. Biological Pathways Regardless of Differences Related to Life-style and Ethnicity
(Doctoral thesis, 2012-02-02)Oral squamous cell carcinoma (OSCC) is a major health problem in many developing countries, representing more than 25% of all new cancer cases in some countries such as India and Sri Lanka. Cigarette smoking, smokeless ... -
Multimodal imaging of gliomas in the context of evolving cellular and molecular therapies
(Peer reviewed; Journal article, 2014-09-30)The vastmajority ofmalignant gliomas relapse after surgery and standard radio-chemotherapy. Novelmolecular and cellular therapies are thus being developed, targeting specific aspects of tumor growth.While histopathology ... -
Multimodal Imaging of Physiologic Changes Induced by Anti-Angiogenic Therapy in Glioblastoma
(Doctoral thesis, 2014-12-18)Glioblastoma (GBM) is the most frequent and malignant form of primary brain tumors. The standard of care for this disease consists in surgical resection, followed by radiotherapy and chemotherapy. Yet, the infiltrative ...