Browsing Department of Biomedicine by Title
Now showing items 457-476 of 708
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The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma
(Peer reviewed; Journal article, 2019-09-27)Galangin (GG), a flavonoid, elicits a potent antitumor activity in diverse cancers. Here, we evaluated the efficacy of GG in the treatment of human glioblastoma multiforme (GBM) and investigated the molecular basis for its ... -
Natural killer cells in intracranial neoplasms: presence and therapeutic efficacy against brain tumours
(Peer reviewed; Journal article, 2014-01)Natural killer (NK) cells are lymphocytes that play an important role in anti-tumour immunity. Their potential against brain cancer has been demonstrated in vitro and in vivo, both as a direct anti-tumour agent and in ... -
Neoadjuvant chemotherapy in breast cancer-response evaluation and prediction of response to treatment using dynamic contrast-enhanced and diffusion-weighted MR imaging
(Peer reviewed; Journal article, 2011)Objective To explore the predictive value of MRI parameters and tumour characteristics before neoadjuvant chemotherapy (NAC) and to compare changes in tumour size and tumour apparent diffusion coefficient (ADC) during ... -
Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality.
(Peer reviewed; Journal article, 2019-04-11)Summary Emerging evidence suggests that Parkinson's disease (PD), besides being an age-associated disorder, might also have a neurodevelopment component. Disruption of mitochondrial homeostasis has been highlighted as a ... -
Neuronal markers are expressed in human gliomas and NSE knockdown sensitizes glioblastoma cells to radiotherapy and temozolomide
(Peer reviewed; Journal article, 2011-12-20)Background: Expression of neuronal elements has been identified in various glial tumors, and glioblastomas (GBMs) with neuronal differentiation patterns have reportedly been associated with longer survival. However, the ... -
Neuropathy-related mutations alter the membrane binding properties of the human myelin protein P0 cytoplasmic tail
(Peer reviewed; Journal article, 2019-06-07)Schwann cells myelinate selected axons in the peripheral nervous system (PNS) and contribute to fast saltatory conduction via the formation of compact myelin, in which water is excluded from between tightly adhered lipid ... -
New lessons from an “old” drug: A proteomic study of anthracycline-induced apoptosis in acute myelogenous leukemia
(Doctoral thesis, 2007-12-18)Anthracyclines have been first line drugs for more than 3 decades in the treatment of acute myelogenous leukemia (AML). Even though the mechanism of action of anthracyclines has been extensively studied over the years, ... -
A new live-cell reporter strategy to simultaneously monitor mitochondrial biogenesis and morphology
(Peer reviewed; Journal article, 2015-11-24)Changes in mitochondrial amount and shape are intimately linked to maintenance of cell homeostasis via adaptation of vital functions. Here, we developed a new live-cell reporter strategy to simultaneously monitor mitochondrial ... -
A New Look at the Functional Organization of the Golgi Ribbon
(Peer reviewed; Journal article, 2019-08-21)A characteristic feature of vertebrate cells is a Golgi ribbon consisting of multiple cisternal stacks connected into a single-copy organelle next to the centrosome. Despite numerous studies, the mechanisms that link the ... -
A New Method for Isolation of Interstitial Fluid from Human Solid Tumors Applied to Proteomic Analysis of Ovarian Carcinoma Tissue
(Peer reviewed; Journal article, 2011-04-26)Major efforts have been invested in the identification of cancer biomarkers in plasma, but the extraordinary dynamic range in protein composition, and the dilution of disease specific proteins make discovery in plasma ... -
New prodrugs and analogs of the phenazine 5,10-dioxide natural products iodinin and myxin promote selective cytotoxicity towards human acute myeloid leukemia cells
(Journal article, 2021)Novel chemotherapeutic strategies for acute myeloid leukemia (AML) treatment are called for. We have recently demonstrated that the phenazine 5,10-dioxide natural products iodinin (3) and myxin (4) exhibit potent and ... -
New tools to enhance the detection of post-translational modifications: Development and application of a mass spectrometry-based proteomic software and of specific antibodies detecting propionylated lysines
(Master thesis, 2009-08-02)Mass spectrometry based proteomics has evolved into a powerful tool in characterising proteins and their respective function in the cell. A proteins cellular localisation, concentration and activity is regulated by several ... -
NK cells with KIR2DS2 immunogenotype have a functional activation advantage to efficiently kill glioblastoma and prolong animal survival
(Peer reviewed; Journal article, 2014-12)Glioblastomas (GBMs) are lethal brain cancers that are resistant to current therapies. We investigated the cytotoxicity of human allogeneic NK cells against patient-derived GBM in vitro and in vivo, as well as mechanisms ... -
NMDA receptor-dependent regulation of miRNA expression and association with Argonaute during LTP in vivo
(Peer reviewed; Journal article, 2014-01-13)microRNAs (miRNAs) are major regulators of protein synthesis in the brain. A major goal is to identify changes in miRNA expression underlying protein synthesis-dependent forms of synaptic plasticity such as long-term ... -
No Protection against DSS-induced Colitis by Short-term Pretreatment with Seal or Fish Oils in Rats
(Peer reviewed; Journal article, 2007-04-30)Background: Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) have modulating effects in several chronic infl ammatory conditions. The aim of the present study was to test whether prior short-term dietary supplementation ... -
Normalized gradient fields for nonlinear motion correction of DCE-MRI time series
(Peer reviewed; Journal article, 2014-04)Dynamic MR image recordings (DCE-MRI) of moving organs using bolus injections create two differenttypes of dynamics in the images: (i) spatial motion artifacts due to patient movements, breathing andphysiological pulsations ... -
Novel clearance of muscle proteins by muscle cells
(Journal article; Peer reviewed, 2020)Blood levels of cardiac troponins (cTn) and myoglobin are analysed when myocardial infarction (MI) is suspected. Here we describe a novel clearance mechanism for muscle proteins by muscle cells. The complete plasma clearance ... -
A novel GFP nude rat model to investigate tumor-stroma interactions
(Peer reviewed; Journal article, 2014-12-21)Backgroud: A key strategy for the study of the tumor microenvironment is to implant human tumor cells in an immunodeficient rodent strain ubiquitously expressing a fluorescent marker. Here, a novel nude rat expressing a ... -
Novel Insights into Integrin α11 Expression and Function
(Doctoral thesis, 2020-01-31)Integrins are a major group of cell surface receptors, which link the extracellular matrix with the cell cytoskeleton. They are heterodimeric proteins consisting of non- covalently bound α- and β-subunits. By regulating ... -
Novel loci associated with attention-deficit/hyperactivity disorder are revealed by leveraging polygenic overlap with educational attainment
(Peer reviewed; Journal article, 2018-02)Objective Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable psychiatric condition. By exploiting the reported relationship between ADHD and educational attainment (EA), we aimed to improve ...