Blar i Department of Biomedicine på tittel
Viser treff 590-609 av 742
-
The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons
(Peer reviewed; Journal article, 2017-11)Brain-derived neurotrophic factor (BDNF) is an important mediator of long-term synaptic potentiation (LTP) in the hippocampus. The local effects of BDNF depend on the activation of translation activity, which requires the ... -
The Role of Age in Cellular Responses to Microenvironmental Cues as a Breast Cancer Susceptibility Factor
(Doctoral thesis, 2016-05-09)Aging is the critical risk factor for many forms of cancer. We used the mammary gland as a model system to study the impact of age on human epithelia in which age is the greatest risk factor for cancer. Dysfunctional ... -
The role of autoantibodies in cell mediated autoimmune Addison`s disease
(Master thesis, 2012-05-31)Background: Addison`s disease (primary adrenal insufficiency) is a prototypic organ-specific autoimmune disease affecting the adrenal cortex. Autoimmune Addison`s disease (AAD) is often characterized by autoantibodies ... -
The Role of Axl in Cancer and Stem Cell Plasticity: in vivo Lineage Tracing and Imaging Mass Cytometry Analysis
(Master thesis, 2019-11-14) -
The role of Axl in melanoma metastasis
(Master thesis, 2015-05-31)Melanoma is a highly invasive and metastatic cancer, thus understanding the mechanism of melanoma metastasis is a major issue. In our study, the objective is to elucidate the role of the receptor tyrosine kinase Axl in ... -
Role of Caveolin-1 in Hypoxia and Proneural to Mesenchymal Transition of Glioblastoma
(Master thesis, 2018-06-29)Glioblastomas (GBM), a grade IV astrocytoma, is the most common and aggressive primary brain tumors in adults, associated with short survival and uniformly fatal outcome irrespective of treatment. GBM is highly heterogeneous ... -
Role of gingival lymphatics in tissue fluid balance and periodontal disease development
(Doctoral thesis, 2012-05-25)Background: The gingiva is frequently challenged to oral bacteria which are able to induce inflammatory responses with increased fluid filtration and edema formation in the tissue. Under given circumstances periodontal ... -
Role of integrin α11β1 in breast cancer
(Doctoral thesis, 2021-09-24)Breast cancer cells are strongly influenced by a complex tumor microenvironment comprised of a diversity of stromal cells, including a heterogeneous population of cancer associated fibroblasts (CAFs), in addition to the ... -
The role of the intermediate compartment in membrane traffic during different stages of the cell cycle
(Master thesis, 2011-06-01)The biosynthetic-secretory pathway delivers newly synthesized molecules from the endoplasmic reticulum (ER) to the plasma membrane (PM), as well as to endomembrane compartments. The intermediate compartment (IC) is an ... -
The Roles of EXT-Like Proteins in Heparan Sulphate Biosynthesis
(Doctoral thesis, 2011-02-11)Heparan sulphate (HS) proteoglycans, composed of a core protein and one or more negatively charged HS chains, are a major component of extracellular matrices and are located on the plasma membrane of all animal cells. The ... -
Roles of extracellular vesicles in glioblastoma: foes, friends and informers
(Journal article; Peer reviewed, 2023)Glioblastoma (GB) tumors are one of the most insidious cancers which take over the brain and defy therapy. Over time and in response to treatment the tumor and the brain cells in the tumor microenvironment (TME) undergo ... -
Roles of Myosin Va and Rab3D in Membrane Remodeling of Immature Secretory Granules
(Peer reviewed; Journal article, 2010-12-22)Neuroendocrine secretory granules (SGs) are formed at the trans-Golgi network (TGN) as immature intermediates. In PC12 cells, these immature SGs (ISGs) are transported within seconds to the cell cortex, where they move ... -
SearchGUI: a highly adaptable common interface for proteomics search and de novo engines
(Peer reviewed; Journal article, 2018)Mass-spectrometry-based proteomics has become the standard approach for identifying and quantifying proteins. A vital step consists of analyzing experimentally generated mass spectra to identify the underlying peptide ... -
Segmentation-Driven Image Registration-Application to 4D DCE-MRI Recordings of the Moving Kidneys
(Peer reviewed; Journal article, 2014-04-01)Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) of the kidneys requires proper motion correction and segmentation to enable an estimation of glomerular filtration rate through pharmacokinetic modeling. ... -
Selectivity of the collagen-binding integrin inhibitors, TC-I-15 and obtustatin
(Journal article; Peer reviewed, 2021)Integrins are a family of 24 adhesion receptors which are both widely-expressed and important in many pathophysiological cellular processes, from embryonic development to cancer metastasis. Hence, integrin inhibitors are ... -
Semaphorin 3A and Class 4 Semaphorins in Tooth Innervation and Development
(Doctoral thesis, 2014-10-10)Background: Dental trigeminal axon elongation, navigation and patterning occur in a controlled manner that is intimately linked to tooth shape formation and cell differentiation. Development of tooth results from sequential ... -
Semi-automatic 3D morphological reconstruction of neurons with densely branching morphology: Application to retinal AII amacrine cells imaged with multi-photon excitation microscopy
(Peer reviewed; Journal article, 2017-03)Background: Accurate reconstruction of the morphology of single neurons is important for morphometric studies and for developing compartmental models. However, manual morphological reconstruction can be extremely time-consuming ... -
Sensing foul AIRE: Investigating possible reporter genes for AIRE mutations
(Master thesis, 2018-06-29)The autoimmune regulator protein, known as AIRE, is a potent transcriptional regulator active in medullary thymic epithelial cells (mTECs) of the thymus, where it is able to switch on the expression of thousands of genes ... -
Sequential bortezomib and temozolomide treatment promotes immunological responses in glioblastoma patients with positive clinical outcomes: A phase 1B study
(Journal article; Peer reviewed, 2020)Background Glioblastoma (GBM) is an aggressive malignant brain tumor where median survival is approximately 15 months after best available multimodal treatment. Recurrence is inevitable, largely due to O6 methylguanine ... -
Serine 19 phosphorylation and 14‐3‐3 binding regulate phosphorylation and dephosphorylation of tyrosine hydroxylase on serine 31 and serine 40
(Peer reviewed; Journal article, 2019-09-17)Multisite phosphorylation and structural flexibility allow for complex regulation of proteins through cellular signaling. Tyrosine hydroxylase (TH), a key enzyme of catecholamine synthesis, is regulated by multiple neuronal ...