Blar i Department of Clinical Medicine på tittel
Viser treff 1329-1348 av 2116
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Mitochondrial respiratory chain deficiency correlates with the severity of neuropathology in sporadic Creutzfeldt-Jakob disease
(Journal article; Peer reviewed, 2020)Mitochondrial dysfunction has been implicated in multiple neurodegenerative diseases but remains largely unexplored in Creutzfeldt-Jakob disease. Here, we characterize the mitochondrial respiratory chain at the individual ... -
Mitochondrial respiratory chain dysfunction—A hallmark pathology of idiopathic Parkinson’s disease?
(Journal article; Peer reviewed, 2022)Parkinson’s disease (PD) is the most common age-dependent neurodegenerative synucleinopathy. Loss of dopaminergic neurons of the substantia nigra pars compacta, together with region- and cell-specific aggregations of ... -
Mitokondriesykdom forårsaket av m.3243A>G-mutasjonen
(Journal article; Peer reviewed, 2022)Mitokondriesykdom er blant de vanligste metabolske sykdommene og er relevant for mange medisinske spesialiteter. Denne kliniske oversiktsartikkelen omtaler en av de vanligste mutasjonene bak mitokondriesykdom: m.3243A>G. ... -
Modic changes-Their associations with low back pain and activity limitation: A systematic literature review and meta-analysis
(Peer reviewed; Journal article, 2018-08-01)Background: Previous systematic reviews have reported positive associations between Modic changes (MCs) and low back pain (LBP), but due to their narrow scope and new primary studies, there is a need for a comprehensive ... -
Modifiable and non-modifiable risk factors in hip fracture mortality in Norway, 2014 to 2018 - a linked multiregistry study
(Journal article; Peer reviewed, 2022)Aims This study aimed to identify risk factors (patient, healthcare system, and socioeconomic) for mortality after hip fractures and estimate their relative importance. Further, we aimed to elucidate mortality and survival ... -
Modulating the unfolded protein response with ONC201 to impact on radiation response in prostate cancer cells
(Journal article; Peer reviewed, 2021)Prostate cancer (PCa) is the most common non-cutaneous cancer in men and a notable cause of cancer mortality when it metastasises. The unfolded protein response (UPR) can be cytoprotective but when acutely activated can ... -
Molecular approaches to the diagnosis and evaluation of follicular lymphoma
(Doctoral thesis, 2015-05-27)Background: Molecular studies of immunoglobulin (IG) genes have provided insights into the pathogenesis of different lymphoid malignancies and allowed the development of useful diagnostic tools as well as powerful prognostic ... -
Molecular biology in pancreatic ductal adenocarcinoma: implications for future diagnostics and therapy
(Peer reviewed; Journal article, 2019)Background: Novel technology has enabled researchers to better characterize pancreatic cancers at the molecular level. We wanted to explore some of the emerging discoveries, such as molecular subclassification, use of ... -
Molecular crosstalk between cancer cells and tumor microenvironment components suggests potential targets for new therapeutic approaches in mobile tongue cancer
(Peer reviewed; Journal article, 2012)We characterized tumor microenvironment (TME) components of mobile tongue (MT) cancer patients in terms of overall inflammatory infiltrate, focusing on the protumorigenic/anti-inflammatory phenotypes and on cancer-associated ... -
Molecular dysfunction associated with the human mitochondrial 3302A>G mutation in the MTTL1 (mt-tRNA Leu(UUR))) gene
(Peer reviewed; Journal article, 2006-11-27)The gene encoding mt-tRNALeu(UUR), MT-TL1, is a hotspot for pathogenic mtDNA mutations. Amongst the first to be described was the 3302A>G transition which resulted in a substantial accumulation in patient muscle of RNA19, ... -
Molecular mechanisms of mitochondrial dysfunction in neurodegenerative diseases
(Doctoral thesis, 2024-06-05)Bakgrunn Nevrodegenerative lidelser er komplekse lidelser i sentralnervesystemet som er typisk preget av akkumulering av feilfoldede proteiner og progressiv degenerasjon og død av sårbare cellepopulasjoner i de berørte ... -
Molecular pathogenesis of polymerase gamma-related neurodegeneration
(Peer reviewed; Journal article, 2014-07)Objective: Polymerase gamma (POLG) mutations are a common cause of mitochondrial disease and have also been linked to neurodegeneration and aging. We studied the molecular mechanisms underlying POLG-related neurodegeneration ... -
Molecular subtypes in stage II-III colon cancer defined by genomic instability: Early recurrence-risk associated with a high copy-number variation and loss of RUNX3 and CDKN2A
(Peer reviewed; Journal article, 2015-04-16)Objective: We sought to investigate various molecular subtypes defined by genomic instability that may be related to early death and recurrence in colon cancer. Methods: We sought to investigate various molecular subtypes ... -
Molecular Subtypes of Breast Cancer: Long-term Incidence Trends and Prognostic Differences
(Peer reviewed; Journal article, 2016-12)Background: Secular trends in incidence and prognosis of molecular breast cancer subtypes are poorly described. We studied long-term trends in a population of Norwegian women born 1886–1977. Methods: A total of 52,949 women ... -
Molecular subtypes, histopathological grade and survival in a historic cohort of breast cancer patients
(Peer reviewed; Journal article, 2013-08)Molecular subtyping of breast cancer may provide additional prognostic information regarding patient outcome. However, its clinical significance remains to be established. In this study, the main aims were to discover ... -
Monogenic diabetes and pancreatic exocrine dysfunction in mouse and man
(Doctoral thesis, 2009-12-04)Exocrine and endocrine pancreatic disease is often observed to occur together. The close colocalization of the endocrine and exocrine tissues within one organ, as well as their common embryological ancestry, have given ... -
Month of birth and risk of multiple sclerosis: confoundingand adjustments
(Peer reviewed; Journal article, 2014-02)A month of birth effect on multiple sclerosis (MS) risk has been reported from different countries. Recent critics have suggested that this finding is caused by confounding and that adequately adjusting for year and place ... -
Morbidity and Mortality after Emergency and Urgent Colorectal Surgery for Malignant and Benign Disease
(Peer reviewed; Journal article, 2009)Abstract: Aim: The aim of this study was to determine short and long-term morbidity and mortality rates after emergency colorectal surgery for benign and malignant disease in a high volume tertiary referral hospital in ... -
More Than Fish—Framing Aquatic Animals within Sustainable Food Systems
(Journal article; Peer reviewed, 2022)Aquatic animals are diverse in terms of species, but also in terms of production systems, the people involved, and the benefits achieved. In this concept piece, we draw on literature to outline how the diversity of aquatic ...