Browsing Department of Biomedicine by Title
Now showing items 597-616 of 742
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Role of integrin α11β1 in breast cancer
(Doctoral thesis, 2021-09-24)Breast cancer cells are strongly influenced by a complex tumor microenvironment comprised of a diversity of stromal cells, including a heterogeneous population of cancer associated fibroblasts (CAFs), in addition to the ... -
The role of the intermediate compartment in membrane traffic during different stages of the cell cycle
(Master thesis, 2011-06-01)The biosynthetic-secretory pathway delivers newly synthesized molecules from the endoplasmic reticulum (ER) to the plasma membrane (PM), as well as to endomembrane compartments. The intermediate compartment (IC) is an ... -
The Roles of EXT-Like Proteins in Heparan Sulphate Biosynthesis
(Doctoral thesis, 2011-02-11)Heparan sulphate (HS) proteoglycans, composed of a core protein and one or more negatively charged HS chains, are a major component of extracellular matrices and are located on the plasma membrane of all animal cells. The ... -
Roles of extracellular vesicles in glioblastoma: foes, friends and informers
(Journal article; Peer reviewed, 2023)Glioblastoma (GB) tumors are one of the most insidious cancers which take over the brain and defy therapy. Over time and in response to treatment the tumor and the brain cells in the tumor microenvironment (TME) undergo ... -
Roles of Myosin Va and Rab3D in Membrane Remodeling of Immature Secretory Granules
(Peer reviewed; Journal article, 2010-12-22)Neuroendocrine secretory granules (SGs) are formed at the trans-Golgi network (TGN) as immature intermediates. In PC12 cells, these immature SGs (ISGs) are transported within seconds to the cell cortex, where they move ... -
SearchGUI: a highly adaptable common interface for proteomics search and de novo engines
(Peer reviewed; Journal article, 2018)Mass-spectrometry-based proteomics has become the standard approach for identifying and quantifying proteins. A vital step consists of analyzing experimentally generated mass spectra to identify the underlying peptide ... -
Segmentation-Driven Image Registration-Application to 4D DCE-MRI Recordings of the Moving Kidneys
(Peer reviewed; Journal article, 2014-04-01)Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) of the kidneys requires proper motion correction and segmentation to enable an estimation of glomerular filtration rate through pharmacokinetic modeling. ... -
Selectivity of the collagen-binding integrin inhibitors, TC-I-15 and obtustatin
(Journal article; Peer reviewed, 2021)Integrins are a family of 24 adhesion receptors which are both widely-expressed and important in many pathophysiological cellular processes, from embryonic development to cancer metastasis. Hence, integrin inhibitors are ... -
Semaphorin 3A and Class 4 Semaphorins in Tooth Innervation and Development
(Doctoral thesis, 2014-10-10)Background: Dental trigeminal axon elongation, navigation and patterning occur in a controlled manner that is intimately linked to tooth shape formation and cell differentiation. Development of tooth results from sequential ... -
Semi-automatic 3D morphological reconstruction of neurons with densely branching morphology: Application to retinal AII amacrine cells imaged with multi-photon excitation microscopy
(Peer reviewed; Journal article, 2017-03)Background: Accurate reconstruction of the morphology of single neurons is important for morphometric studies and for developing compartmental models. However, manual morphological reconstruction can be extremely time-consuming ... -
Sensing foul AIRE: Investigating possible reporter genes for AIRE mutations
(Master thesis, 2018-06-29)The autoimmune regulator protein, known as AIRE, is a potent transcriptional regulator active in medullary thymic epithelial cells (mTECs) of the thymus, where it is able to switch on the expression of thousands of genes ... -
Sequential bortezomib and temozolomide treatment promotes immunological responses in glioblastoma patients with positive clinical outcomes: A phase 1B study
(Journal article; Peer reviewed, 2020)Background Glioblastoma (GBM) is an aggressive malignant brain tumor where median survival is approximately 15 months after best available multimodal treatment. Recurrence is inevitable, largely due to O6 methylguanine ... -
Serine 19 phosphorylation and 14‐3‐3 binding regulate phosphorylation and dephosphorylation of tyrosine hydroxylase on serine 31 and serine 40
(Peer reviewed; Journal article, 2019-09-17)Multisite phosphorylation and structural flexibility allow for complex regulation of proteins through cellular signaling. Tyrosine hydroxylase (TH), a key enzyme of catecholamine synthesis, is regulated by multiple neuronal ... -
Serum concentrations of kynurenines in adult patients with attention-deficit hyperactivity disorder (ADHD): a case–control study
(Peer reviewed; Journal article, 2015-11-05)Background: The essential amino acid tryptophan is catabolised mainly through the kynurenine pathway. Altered circulating levels of kynurenines have been reported in chronic inflammatory conditions and in several ... -
Severe traumatic brain injury in Norway: Impact of age on outcome
(Peer reviewed; Journal article, 2013-04-23)Objective: The aim of this study was to investigate the influence of age on mortality and 3-month outcome in a Norwegian cohort of patients with severe traumatic brain injury (TBI). Methods: Norwegian residents ≥ 16 years ... -
Sex differences in parent–offspring recurrence of attention-deficit/hyperactivity disorder
(Journal article; Peer reviewed, 2020)Background Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable neurodevelopmental disorder sharing genetic risk factors with other common psychiatric disorders. However, intergenerational recurrence ... -
Shanks - multidomain molecular scaffolds of the postsynaptic density
(Peer reviewed; Journal article, 2019-03-06)The postsynaptic density (PSD) is a protein-rich assembly below the postsynaptic membrane, formed of large scaffolding proteins. These proteins carry a combination of protein interaction domains, which may interact with ... -
Shedding light on black boxes in protein identification
(Peer reviewed; Journal article, 2014-05)Performing a well thought-out proteomics data analysis can be a daunting task, especially for newcomers to the field. Even researchers experienced in the proteomics field can find it challenging to follow existing publication ... -
Short-term duodenal seal oil administration normalised n-6 to n-3 fatty acid ratio in rectal mucosa and ameliorated bodily pain in patients with inflammatory bowel disease
(Peer reviewed; Journal article, 2006-03-20)Background: A high dietary intake of n-6 compared to n-3 fatty acids (FAs) may promote the production of pro-inflammatory eicosanoids and cytokines. In two recent studies, short-term (10- day) duodenal administration of ... -
A simple DMSO-based method for cryopreservation of primary hippocampal and cortical neurons
(Peer reviewed; Journal article, 2019-03)Background Primary neuronal cultures are widely used to elucidate fundamental aspects of neuronal anatomy, physiology, cell biology, and neuronal dysfunction in animal models of disease. However, preparation of primary ...